Niveles de neopterina y síndrome de respuesta inflamatoria sistémica en pacientes críticos pediátricos

Gil-Gómez, Raquel; Blasco‐Alonso, Javier; Sánchez-Yáñez, Pilar; Rosa-Camacho, Vanessa; Manso, G. Milano

doi:10.1016/j.anpedi.2016.11.011

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Para contener la inflamación, los macrófagos comienzan de inmediato sus acciones fagocitarias (John E. Hall & Michael E. Hall, 2021) Neopterina: es un marcador que refleja la respuesta de los macrófagos a la inflamación, aumentando cuando se producen alteraciones relaciones con la activación del sistema inmune. Mide el nivel de inflamación, ya sea producida por un traumatismo, una infección o hasta una bacteria (Gieseg et al, 2018;Gil-Gómez et al, 2017;Melichar et al, 2017).…”

Section: Recuperación Musculoesqueléticaunclassified

Efectividad de la crioterapia en la recuperación musculoesquelética de los artistas marciales: Revisión sistemática (Effectiveness of cryotherapy in the musculoskeletal recovery of martial artists: Systematic review)

Jódar Llinás,

Castellote Caballero

2024

Retos

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La recuperación de los artistas marciales mediante la inmersión del cuerpo en agua fría es un método muy utilizado para el restablecimiento de la condición física y la mejora del rendimiento. Objetivo: examinar y agrupar, de forma crítica, las principales evidencias científicas disponibles en la actualidad sobre la efectividad de la crioterapia en la recuperación de los artistas marciales. Materiales y métodos: la búsqueda se llevó a cabo en las bases de datos Pubmed, PEDro, Scielo, Scopus y Google Scholar con las palabras clave “Cryotherapy”, “Muscle fatigue”, “Martial arts” y “MMA”. Tras la búsqueda bibliográfica se seleccionaron siete artículos en total para la revisión. Las principales variables analizadas fueron: marcadores de daño y fatiga muscular, percepción de fatiga, potencia de miembros superiores y potencia de miembros inferiores. Resultados: Todos los estudios cumplieron con los criterios de inclusión y exclusión y fueron clasificados en el grupo de crioterapia vs recuperación pasiva. Conclusión: existe una evidencia sólida sobre la efectividad de la crioterapia en la disminución del dolor percibido en artistas marciales. También existe una evidencia moderada de la efectividad de la crioterapia en la disminución de la concentración de ácido láctico (LDH), creatina quinasa (CK), cortisol y neopterina y en la recuperación de la fuerza. Palabras clave: Crioterapia, Fatiga muscular, Artes marciales, MMA, Dolor. Abstract. Recovery of martial artists by immersing their body in cold water has been a widely used method for restoring physical fitness and improving performance. Objective: to critically examine and group the main scientific evidence currently available on the effectiveness of cryotherapy in the recovery of martial artists. Materials and methods: the search was carried out in the databases Pubmed, PEDro, Scielo, Scopus and Google Scholar with the keywords "Cryotherapy", "Muscle fatigue", "Martial arts" and "MMA". After the literature search, a total of seven items were chosen for the review. The main variables analyzed were markers of muscle damage and fatigue, perception of fatigue, upper limb power and lower limb power. Results: All studies met the inclusion and exclusion criteria and were classified in the cryotherapy vs passive recovery group. Conclusion: There is strong evidence for the effectiveness of cryotherapy in decreasing perceived pain in martial artists. There is also moderate evidence for the effectiveness of cryotherapy in decreasing lactic acid (LDH), creatine kinase (CK), cortisol and neopterin concentration and in strength recovery. Key words: Cryotherapy, Muscle fatigue, Martial arts, MMA, Pain.

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Section: Recuperación Musculoesqueléticaunclassified

Efectividad de la crioterapia en la recuperación musculoesquelética de los artistas marciales: Revisión sistemática (Effectiveness of cryotherapy in the musculoskeletal recovery of martial artists: Systematic review)

Jódar Llinás,

Castellote Caballero

2024

Retos

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Biomarkers in Pediatric Sepsis: A Review of Recent Literature

et al. 2020

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Sepsis remains the leading cause of death in infants and children worldwide. Prompt diagnosis and monitoring of infection is pivotal to guide therapy and optimize outcomes. No single biomarker has so far been identified to accurately diagnose sepsis, monitor response and predict severity. We aimed to assess existing evidence of available sepsis biomarkers, and their utility in pediatric population. C-reactive protein and procalcitonin remain the most extensively evaluated and used biomarkers. However, biomarkers related to endothelial damage, vasodilation, oxidative stress, cytokines/chemokines and cell bioproducts have also been identified, often with regard to the site of infection and etiologic pathogen; still, with controversial utility. A multi-biomarker model driven by genomic tools could establish a personalized approach in future disease management.

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High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin

et al. 2023

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Among the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is the lack of effective prognostic markers. Neopterin, which is a marker of monocyte/macrophage activation, was found have increased during severe malaria. In this study, we used quantitative ELISA in order to assess the levels of plasma soluble neopterin in 151 patients from a cohort of Beninese children with severe malaria. We evaluated the prognostic accuracy of this molecule in order to predict the outcome of the disease. Our results show that neopterin levels were not significantly different between patients with different forms of severe malaria, including severe non-cerebral malaria (SNCM) and cerebral malaria (CM). However, the levels of this molecule were found to be higher in patients with severe malarial anemia (SMA) among both CM and SNCM cases (p-value = 0.02). Additionally, the levels of this molecule were found to be higher in patients who died from these pathologies compared to those who survived among the two clinical groups (p-value < 0.0001) and within the same group (p-value < 0.0001 for the CM group, p-value = 0.0046 for the SNCM group). The AUC-ROC for fatality among all the severe cases was 0.77 with a 95%CI of (0.69–0.85). These results suggest that plasma neopterin levels constitute a potential biomarker for predicting fatality among severe falciparum malaria patients.

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Niveles de neopterina y síndrome de respuesta inflamatoria sistémica en pacientes críticos pediátricos

Abstract: There is a higher neopterin level when there is a longer PICU stay, higher VIS score, longer time on MV, and occurrence of complications, indicating the involvement of an activation of the cellular immune system.

Cited by 3 publications

References 17 publications

Efectividad de la crioterapia en la recuperación musculoesquelética de los artistas marciales: Revisión sistemática (Effectiveness of cryotherapy in the musculoskeletal recovery of martial artists: Systematic review)

Efectividad de la crioterapia en la recuperación musculoesquelética de los artistas marciales: Revisión sistemática (Effectiveness of cryotherapy in the musculoskeletal recovery of martial artists: Systematic review)

Biomarkers in Pediatric Sepsis: A Review of Recent Literature

High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin

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