Niveles séricos de la isoenzima creatina quinasa-MB y lactato deshidrogenasa como indicadores de daño miocárdico en perros con enfermedad valvular degenerativa

Sepúlveda, R.; Paredes, Manuel Alexis Saldivia; Vásquez, S.

doi:10.15446/rfmvz.v69n1.101533

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…Though the CK-MB is more speci c in cardiac muscles yet it has low activity in other bodily tissues such as skeletal, brain, uterus and brain. Increased levels of both these biomarkers in various livestock and pet animals affected with any of the cardiac pathologies have been reported earlier(Nikvand et al, 2019;Xu et al, 2020;Sepulveda, et al, 2022). .035 ± 0.015ng/mL(Kirbas et al, 2014) which is lower than the value of the present study.…”

contrasting

confidence: 71%

“…An even lower value of 120.9 ± 4.4U/L has been reported for sheep of Greece(Katsoulos et al, 2010). This difference and a wide range of RIs presented in prior work as well as of the present study indicate a wide variation in this attribute as per geo-location, feeding regimen and method of determining LDH(Katsoulos et al, 2010;Sepulveda et al, 2022).…”

contrasting

confidence: 65%

“…Regarding veterinary medical sciences and ascertaining of cardiac biomarkers for livestock, increased levels of aforementioned cardiac biomarkers in various cattle breeds and pet animals affected with any of the cardiac pathologies have been reported globally (Nikvand et al 2019;Sepulveda et al 2022).…”

Section: Introductionmentioning

confidence: 99%

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Physiological Dynamism of Various Serum Cardiac Biomarkers in Apparently Healthy Sipli Sheep of Pakistan

Sharif,

Lashari,

Farooq

et al. 2024

Preprint

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The present work is the first record of deducing normal reference intervals (RIs) for various serum cardiac biomarkers namely cardiac troponin I (cTnI), alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), creatine kinase-myocardial band (CK-MB), sodium (Na+), potassium (K+) and total protein (TP), and their interrelationship in apparently healthy indigenous Sipli breed of sheep (n = 141) from Pakistan. Apropos to aseptic blood collection and serum extraction, the attributes were deduced using commercially available kits. For the sake of analyses, the studied biomarkers were attributed as independent (Na+, K+, and TP) and dependent (LDH, ALT, AST, cTnI and CK-MB) variables. The RIs were determined through Reference Value Advisor Version 2.1 as per gender and age keeping in view the guidelines provided by American Society of Veterinary Pathology (ASVCP). Results revealed that the RIs for cardiac serum biomarkers included in the present study were generally within the reference range provided for sheep with slight variations which might be attributed to physiological adaptation to harsh desert climate. The Na+ significantly (P ≤ 0.05) predicted AST (adj. r-square = 0.976) and CK-MB (adj. r-square = 0.477). Similarly, K+ significantly (P ≤ 0.05) predicted LDH (adj. r-square = 0.626) and ALT (adj. r-square = 0.897). The TP had highest adjusted r-square of 0.770 with AST however it was statistically non-significant (P ≥ 0.05). The results of the study present a baseline data about these cardiac biomarkers which may be utilized for cardiac assessment of the sheep. It is recommended that the serum cardiac biomarkers ascertained in this study may be studied along with electrophysiology and ultrasonography of sheep heart for confirmed diagnosis/prognosis of cardiomyopathies.

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contrasting

confidence: 71%

contrasting

confidence: 65%

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Physiological Dynamism of Various Serum Cardiac Biomarkers in Apparently Healthy Sipli Sheep of Pakistan

Sharif,

Lashari,

Farooq

et al. 2024

Preprint

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“…Las disfunciones del corazón llevan a remodelamiento ventricular e isquemia, generando liberación de marcadores biológicos como las enzimas (Sepúlvada, Saldivia, & Vásquez, 2022). Reis y cols.…”

Section: Resultados Y Discusiónunclassified

Creatin - quinasa sérica como Biomarcador para infarto de miocardio en adultos mayores

Genesis Lisseth,

Jerithza Fabiana,

Jefferson Joel

et al. 2023

Pentaciencias

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La creatin quinasa en suero CK es una enzima cardiaca que es segregada ante lesiones cardiacas o ejercicio extenuante. Los adultos mayores suelen presentar diversas comorbilidades, entre las más comunes están las complicaciones cardiacas. Se ha estudiado la utilidad de la creatin quinasa como biomarcador en el diagnóstico ante un infarto agudo de miocardio en esta población. Por esta razón el presente trabajo bibliográfico se plantea como pregunta de investigación ¿Se puede tomar la creatin - quinasa sérica como un biomarcador confiable para infarto de miocardio en adultos mayores? El trabajo es una revisión bibliográfica con metodología de tipo descriptiva y documental, en la que se toman datos referentes al tema de estudio de otros trabajos académicos, por ejemplo, de artículos científicos, reportes, tesis, etc. Los resultados de las investigaciones elegidas demuestran la efectividad del análisis de la creatin quinasa y su elevación en su concentración sérica como marcador confiable para detectar complicaciones cardiacas en adultos mayores.

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Niveles séricos de la isoenzima creatina quinasa-MB y lactato deshidrogenasa como indicadores de daño miocárdico en perros con enfermedad valvular degenerativa

Cited by 2 publications

References 8 publications

Physiological Dynamism of Various Serum Cardiac Biomarkers in Apparently Healthy Sipli Sheep of Pakistan

Physiological Dynamism of Various Serum Cardiac Biomarkers in Apparently Healthy Sipli Sheep of Pakistan

Creatin - quinasa sérica como Biomarcador para infarto de miocardio en adultos mayores

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