2005
DOI: 10.1016/j.clinthera.2005.04.008
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Nizatidine for the treatment of pediatric gastroesophageal reflux symptoms: An open-label, multiple-dose, randomized, multicenter clinical trial in 210 children

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Cited by 22 publications
(13 citation statements)
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“…Até o momento, apenas a cimetidina 25 e a nizatidina 26,27 foram avaliadas em crianças em relação à evolução clínica da DRGE através de estudos controlados e randomizados. A cimetidina apresenta um grande número de interações medicamentosas.…”
Section: Esofagite Erosivaunclassified
See 1 more Smart Citation
“…Até o momento, apenas a cimetidina 25 e a nizatidina 26,27 foram avaliadas em crianças em relação à evolução clínica da DRGE através de estudos controlados e randomizados. A cimetidina apresenta um grande número de interações medicamentosas.…”
Section: Esofagite Erosivaunclassified
“…Trinta e dois por cento dos pacientes alcançaram melhora total dos sintomas após 8 semanas de uso da droga 27 . Apesar do número significativo de pacientes envolvidos, esse estudo sugere uma eficácia limitada da droga, ou, mais provavelmente, uma dificuldade em avaliar a DRGE a partir de sintomas clínicos.…”
Section: Esofagite Erosivaunclassified
“…This makes H 2 RAs well suited to "on-demand" use. Another plus for these drugs is that there are pediatric data supporting the use and safety of the H 2 RAs cimetidine, ranitidine, nizatidine, and famotidine in infants and children [27][28][29][30]. Cimetidine tends to be less frequently used in children, as it has more side effects than the others.…”
Section: H 2 Rasmentioning
confidence: 93%
“…The current knowledge on children with GERD is mainly drawn from countless case series reports about H2-receptor antagonists date, cimetidine 25 and nizatidine 26,27 are the only H2-receptor antagonists (H2RA) that have been evaluated in controlled and randomized trials with children in terms of GERD outcome. Cimetidine has been known to present a large number of drug interactions.…”
Section: The Young Child With Abdominal Painmentioning
confidence: 99%
“…Thirty two percent of patients achieved complete relief from symptoms after 8 weeks of treatment. 27 Despite the large number of patients involved, the study suggests either a limited efficacy of the drug or most likely the difficulty to assess GERD based on clinical symptoms. Furthermore, regarding drug safety, several adverse effects, such as upper respiratory tract infections, vomiting, diarrhea, pneumonia, dermatitis, fatigue and tremor were recorded.…”
Section: The Young Child With Abdominal Painmentioning
confidence: 99%