Nizatidine Improves Clinical Symptoms and Gastric Emptying in Patients with Functional Dyspepsia Accompanied by Impaired Gastric Emptying

Futagami, Seiji; Shimpuku, Mayumi; Song, Jeong-Yeop; Kodaka, Yasuhiro; Yanagawa, Hiroshi; Nagoya, Hiroyuki; Shindo, Tetsuya; Kawagoe, Tetsuro; Horie, Akane; Gudis, Katya; Iwakiri, Katsuhiko; Sakamoto, Choitsu

doi:10.1159/000339111

Cited by 33 publications

(23 citation statements)

References 77 publications

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“…A randomized, controlled trial in adults found that PPI therapy improved symptoms only in FD patients with concurrent heartburn [145] . Whether the therapeutic benefit is related to acid hypersensitivity is not clear as these medications may be treating a component of acid mucosal injury or co-morbid GERD, or may also improve dyspeptic symptoms related to delayed gastric emptying [146] . Still, acid reduction therapy remains the most common treatment prescribed empirically by pediatric gastroenterologists for FD in children [147] .…”

Section: Targeting Visceral Hypersensitivitymentioning

confidence: 99%

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

Rosen

Cocjin

Schurman

et al. 2014

WJGPT

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Functional gastrointestinal disorders (FGID) are common clinical syndromes diagnosed in the absence of biochemical, structural, or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age, geography, and culture. Etiology of abdominal pain associated FGIDs, including functional dyspepsia (FD), remains incompletely understood, but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD, with focus on pediatric data when available, and provides a summary of potential therapeutic targets. Visceral sensitivity and intestinal electromechanical function both are demonstrated to be altered in some FD patients and are potential targets for treatment. Limited studies in pediatric FD are available, but available evidence supports adult data that targeting visceral hypersensitivity and electromechanical dysfunction is warranted, particularly in the context of the biopsychosocial model. Future studies in pediatrics are needed to determine optimal therapy and appropriate patient application.Rosen JM, Cocjin JT, Schurman JV, Colombo JM, Friesen CA. Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia. World

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Section: Targeting Visceral Hypersensitivitymentioning

confidence: 99%

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

Rosen

Cocjin

Schurman

et al. 2014

WJGPT

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“…[22][23][24] We estimated clinical symptoms with the GSRS. 25 The GSRS is composed of 15 items (epigastric pain, epigastric burning, gastroesophageal reflux symptom, eructation, postprandial fullness, abdominal distention, early satiety, abdominal pain, the feeling of hunger, nausea, borborygmus, constipation, diarrhea, loose stools and hard stools) which generated 5 components including gastroesophageal reflux, abdominal pain, dyspepsia, diarrhea and constipation.…”

Section: Clinical Symptomsmentioning

confidence: 99%

Impact of Eating Attitude and Impairment of Physical Quality of Life Between Tertiary Clinic and Primary Clinic Functional Dyspepsia Outpatients in Japan

Shimpuku

Futagami

Tajima³

et al. 2014

J Neurogastroenterol Motil

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Background/Aims There is no available data on factors associated with healthcare-seeking behavior for functional dyspepsia (FD) symptoms at either tertiary or primary clinics in Japan. Therefore, we aimed to compare clinical symptoms and life styles such as sleep disorders and eating attitude in FD patients visiting general practitioners at primary clinics with those consulting gastroenterologists at tertiary clinics to clarify healthcare-seeking patterns in Japanese patients. Methods Fifty-one FD outpatients in a tertiary clinic (college hospital), 50 FD outpatients visiting primary clinics and 50 healthy volunteers were enrolled. Clinical symptoms, quality of life, sleep disorders, eating attitude and anxiety were estimated using the Gastrointestinal Symptom Rating Scale (GSRS), Social Functioning-8 (SF-8) test, Pittsburg Sleep Quality Index (PSQI) test and State-Trait Anxiety Inventory (STAI) for FD outpatients and healthy volunteers. Results FD outpatients exhibited higher mean scores of GSRS than healthy volunteers. The SF-8 physical component summary scores in the tertiary clinic group were significantly lower than those in the primary clinic group. GSRS scores were significantly ( P < 0.001, P = 0.002) associated with global PSQI scores in FD outpatients as well as with STAI-trait scores ( P = 0.006, P = 0.001) compared to healthy volunteers. The frequency of eating between meals in the primary clinic group was significantly ( P < 0.05) higher than that in the tertiary clinic group. Conclusions It may be important for clarification of healthcare-seeking behavior to determine the difference in both impairment of physical quality of life and eating attitudes between tertiary clinic and primary clinic FD outpatients in Japan.

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“…We assessed abdominal symptoms using the modified Glasgow dyspepsia severity score (GDSS) [9,17,23,24], which is based on frequency (never, score 0; on only 1 or 2 days, score 1; on approximately 1 day per week, score 3; on approximately 50% of days, score 4; on most days, score 5), duration (minimun score, 0; maximal score 5), and intensity of symptoms (minimun score, 0; maximal score, 3). Status of depression was evaluated by Self-Rating Questionnaire for Depression (SRQ-D) scores [25].…”

Section: Clinical Symptomsmentioning

confidence: 99%

“…We have reported that prokinetics like mosapride citrate improves clinical symptoms by affecting the T max value in proton pump inhibitor (PPI)-resistant NERD patients with impaired gastric emptying [16]. In addition, we have also reported that nizatidine administration significantly improved both gastric emptying and clinical symptoms in FD patients with impaired gastric emptying [17]. Therefore, we have considered that T max value using 13 C-acetate breath test were the useful marker for treatment of FD patients.…”

Section: Introductionmentioning

confidence: 99%

Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers

Futagami¹

2014

Int J Gastroenterol Disord Ther

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Background/Aims: The association between initial phase of gastric emptying and clinical symptoms and depression status in functional dyspepsia has not been studied in detail. Methods: The subjects were 20 patients with Rome III-based functional dyspepsia and healthy volunteers. We evaluated upper abdominal symptoms using GDSS score and used Self-Rating Questionnaire for Depression (SRQ-D) scores to determine depression status. Gastric motility was evaluated with the 13 C-acetate breath test. Results: AUC 15 value as initial gastric emptying within 15 mins in FD patients was significantly higher compared to that in healthy volunteers. T max value as a marker of delayed gastric emptying in FD patients was also significantly higher compared to that in healthy volunteers. There were not significant relationships between clinical symptoms and AUC 5 and AUC 15 values in FD patients and healthy volunteers. In contrast, there were significant correlations (p=0.047, p=0.049) between SRQ-D score and AUC 5 and AUC 15 values in healthy volunteers, albeit there were not significant correlations in FD patients. Conclusions: Impairment of AUC 15 or AUC 15 /AUC inf as well as delayed gastric emptying would play important roles in functional dyspepsia. Further studies are necessary to clarify whether various clinical symptoms and depression status are related to initial gastric emptying at postprandial 15 mins phase.

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Nizatidine Improves Clinical Symptoms and Gastric Emptying in Patients with Functional Dyspepsia Accompanied by Impaired Gastric Emptying

Cited by 33 publications

References 77 publications

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

Impact of Eating Attitude and Impairment of Physical Quality of Life Between Tertiary Clinic and Primary Clinic Functional Dyspepsia Outpatients in Japan

Distinct Associations Between Depression Status and Initial Phase of Gastric Emptying in Functional Dyspepsia and Healthy Volunteers

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