NK-CDS: A Creative Design System for Museum Art Derivatives

Abstract

At present, designing museum art derivatives attracts more and more attention. Experts in the field often use hand painting or image editing software to process images. This is time-consuming work and requires professional knowledge for design. In order to address this problem, by exploiting the advanced computer simulation and image processing techniques, we develop a novel museum art derivative design system, named NK-CDS. This system consists of element operation and element application modules. Given a cultural relic image, the user extracts the interest region in the image, then processes the appearance of the element by denoising, sharpening, etc. Finally, with the application interface, the user can flexibly map the processed elements to any location of a lifestyle model. This system is intuitive and easy to operate, which can improve the design efficiency of museum derivatives and inspire ideas for creative culture product design. INDEX TERMS Computer simulation, element processing, element application, museum derivatives design.

Key residues influencing binding affinities of 2019-nCoV with ACE2 in different species

“…Then, we selected 18 species (chimpanzee, monkey, totoro, rabbit, tiger, lion, cat, cynomys, dog, rat, sheep, whale, pig, cow, deer, dolphin, duck and chicken) keeping close contacts with human beings for detailed analysis. As bat [ 8 , 9 , 10 ], manis [ 11 ] and snake [ 25 ] were once considered to be the original host of coronavirus to human beings, thus we also take these 3 species for further analysis.…”

“…The most significant improvement of binding affinity was discovered in 3 species including pig, dog and bat. The bat, which possesses the highest binding ability −63.26 kcal/mol, was suspected as the first case of novel coronavirus infection source [ 8 , 9 , 10 ]. It is worth noting that one highly increased binding energy of −61.66 kcal/mol was assigned to the species dog which was reported as the first lethal case infected with 2019-nCoV virus [ 12 , 13 ].…”

“…The bats are unanimously considered to be the main infecting source of the coronavirus [ 8 , 9 , 10 ], and a maximum energy variation (bat: −63.25 kcal/mol, human: −55.07 kcal/mol) occurred with the ordering of different residues in ACE2/2019-nCoV-Spike complexes. The structural data indicated that atoms of the functional group amin -NH 3 from residue K27 on bat ACE2 make new polar contacts with residue Y473 in Spike region, as shown in Figure 7 .…”

“…Now, various researches for finding the original coronavirus 2019-nCoV infecting sources have been conducted [ 5 , 6 ], and some species including Paguma larvata, Nyctereutes procyonoides [ 7 ], Bat [ 8 , 9 , 10 ] have been identified as suspect of the primary hosts of the novel coronavirus. The preliminary assessment indicated that manis might be the intermediate host of virus spreading to human beings by analyzing the evolutionary tree of 2019-nCoV coronavirus [ 11 ].…”