2008
DOI: 10.1111/j.1600-0609.2008.01089.x
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NK‐cell intravascular lymphomatosis – a mini‐review

Abstract: The majority of cases of intravascular lymphomatosis (IVL) is derived from B cells. However, IVL may also arise from T cells, or more rarely NK cells. The clinicopathological findings in six cases of NK‐cell IVL (NK‐IVL), including one new case, were summarised and compared with B‐cell IVL (B‐IVL) and T‐cell IVL (T‐IVL). Earlier onset of disease and female predominance were found in NK‐IVL. NK‐IVL was typically Epstein–Barr virus (EBV)‐positive, whereas EBV was rarely detected in B‐IVL. Cutaneous manifestation… Show more

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Cited by 38 publications
(34 citation statements)
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“…A review of these cases showed median age at presentation was 46 years with a male to female ratio of 1:2. Skin involvement was a predominant finding (83%) while bone marrow involvement was seen in only one case [15]. The unifying feature in all these cases was EBV positivity.…”
Section: Discussionmentioning
confidence: 92%
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“…A review of these cases showed median age at presentation was 46 years with a male to female ratio of 1:2. Skin involvement was a predominant finding (83%) while bone marrow involvement was seen in only one case [15]. The unifying feature in all these cases was EBV positivity.…”
Section: Discussionmentioning
confidence: 92%
“…Cutaneous involvement is present in 39% and 46% of cases of B-and T-cell IVL, respectively, compared with 83% of cases in NK/T-IVL. EBV positivity was rarely detected in B-and T-cell IVL [15].…”
Section: Discussionmentioning
confidence: 94%
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“…Es wird als eine Akkumulation von großen neoplastischen B-Zellen in den Lumina kleiner Gefäße in der Dermis und Subkutis definiert. In sehr seltenen Fällen kann bei einem intravaskulären Lymphom auch ein T-Zelloder NK-Zell-Phänotyp vorliegen, diese gehen mit einer schlechteren Prognose und gelegentlich mit EBV einher [72,73] [74].…”
Section: Introductionunclassified