2008
DOI: 10.1016/j.smim.2008.06.004
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NK gene complex dynamics and selection for NK cell receptors

Abstract: Natural Killer (NK) cells play important roles in innate defense against infectious agents particularly viruses and also tumors. They mediate their effects through direct cytolysis, release of cytokines and regulation of subsequent adaptive immune responses. NK cells are equipped with sophisticated arrays of inhibitory and activation receptors that regulate their function. In this review we illustrate some of the major evolutionary relationships between NK cell receptors among different animal species and what… Show more

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Cited by 29 publications
(39 citation statements)
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“…In contrast, NK cell-mediated defense against MCMV in BALB/c mice differs significantly from that in B6 mice due to a different expression pattern of activating and inhibitory Ly49 family receptors (37), including a lack of Ly49H. Such differences, including the lack of LY49H, also pertain to many other inbred strains and wild mice as well (38). Consequently, we tested if i NKT cells contribute to MCMV innate defense in BALB/c mice lacking Ly49H by analyzing viral replication in the spleen and liver of Jα18 −/− mice and WT littermate controls.…”
Section: Resultsmentioning
confidence: 99%
“…In contrast, NK cell-mediated defense against MCMV in BALB/c mice differs significantly from that in B6 mice due to a different expression pattern of activating and inhibitory Ly49 family receptors (37), including a lack of Ly49H. Such differences, including the lack of LY49H, also pertain to many other inbred strains and wild mice as well (38). Consequently, we tested if i NKT cells contribute to MCMV innate defense in BALB/c mice lacking Ly49H by analyzing viral replication in the spleen and liver of Jα18 −/− mice and WT littermate controls.…”
Section: Resultsmentioning
confidence: 99%
“…Disentangling the contribution of either subset, however, has been difficult without a monospecific reagent to detect Ly49P. A genetic approach to assess the role of the different NK receptors is equally challenging due to the complexity of disrupting a singular Ly49 gene (50) and because of the rare frequency of cross-over events (51) within the Ly49 gene cluster. Moreover, NKC haplotypes associated with MCMV resistance in D k -expressing MA/My and C57L-derived mice encode both Ly49P and a D k -binding G 2 allele, while NKC types in less resistant strains (e.g.…”
Section: Resultsmentioning
confidence: 99%
“…The relative up-or downregulation of transcript levels were generally more pronounced in R17 compared with DA MF, which may reflect that the balance between opposing signals regulates MF effector functions, similar to that described for natural killer cell receptors on natural killer cells. [32][33][34] Another unresolved question concerns which of the APLEC gene(s) exert an impact on innate immunity. Rat Dcar1 is a strong candidate as it appears functional in R17 rats but nonsense mutated in DA rats.…”
Section: Discussionmentioning
confidence: 99%