NK-/T-Cell Lymphoma Resembling Hydroa Vacciniforme With Positive CD4 Marker Expression

Zhang, Guiying; Bai, Harrison X.; Yang, Li; Michael, H.; Y, Su; Luo, Yangyang; Wen, Haiquan; Lu, Qianjin; Xiao, Rong

doi:10.1097/dad.0b013e3182674895

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…Histologically, its atypical lymphocytic infiltration and angiocentric distribution pattern were also similar to EBV-associated HV-like eruption, but it has not been reported to occur in concurrence with HV-like eruption. Zhang et al 10 reported facial HV-like eruptions as nasal type NK/T-cell lymphoma, which is distinct from our case, which had no systemic symptoms or invasion of other organs.…”

Section: Discussioncontrasting

confidence: 44%

Epstein-Barr Virus-Associated Vesiculopapular Eruption on the Face of a Patient with Natural Killer T Cell Lymphoma

2017

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Unlike typical hydroa vacciniforme (HV), Epstein-Barr virus (EBV)-associated HV-like eruption is more variable in its clinical manifestations. In some patients, progression to lymphoma or leukemia has been reported, which are characterized by the T-cell immunophenotype. Here, we report the first Korean case of EBV-associated vesiculopapular eruption on the face of a patient with natural killer (NK)/T cell lymphoma. A 32-year-old Korean man presented with a late adolescent-onset recurrent necrotic papulovesicles on his face. The patient was previously diagnosed with EBV-associated NK/T cell lymphoma of the oral cavity and also had childhood-onset hypersensitivity to mosquito bites. Biopsy of his facial skin showed EBV-associated vesiculopapular eruptions, though ultraviolet provocation did not reproduce the skin lesions. EBV viral load in his peripheral blood was detected but low. The patient was treated with systemic chemotherapy. The lymphoma went into remission, but the facial EBV-associated vesiculopapular eruption had a relapsing and remitting course.

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Section: Discussioncontrasting

confidence: 44%

Epstein-Barr Virus-Associated Vesiculopapular Eruption on the Face of a Patient with Natural Killer T Cell Lymphoma

2017

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“…The extranodal NK/T‐cell lymphoma tumor cells infiltrate in the subcutaneous layer commonly forms a panniculitis‐like pattern . To our knowledge, only two cases of primary cutaneous extra‐nodal NK/T‐cell lymphoma presenting as facial swelling have previously been reported . Our cases suggest that facial swelling is a novel clinical manifestation of cutaneous extranodal NK/T‐cell lymphoma.…”

Section: Discussionmentioning

confidence: 69%

“…A review of the literature revealed 17 cases of facial edema as clinical manifestations of primary cutaneous lymphoma or as accompanying lesions in non‐cutaneous lymphoma in the head and neck area (Table ) . The reports included 11 cases of primary cutaneous lymphoma presenting as facial swelling and six cases with non‐cutaneous lymphoma of the head and neck with accompanying facial swelling.…”

Section: Discussionmentioning

confidence: 99%

“…The reports included 11 cases of primary cutaneous lymphoma presenting as facial swelling and six cases with non‐cutaneous lymphoma of the head and neck with accompanying facial swelling. Of the cases with primary cutaneous lymphoma, two were of extranodal NK/T‐cell lymphoma, one was subcutaneous panniculitis‐like T‐cell lymphoma, one was follicle center lymphoma, and seven were HVL . Subtypes of non‐cutaneous lymphoma in the head and neck area include extranodal NK/T‐cell lymphoma in the nasal cavity, Burkitt's lymphoma, marginal zone B‐cell lymphoma, and B‐cell lymphoma .…”

Section: Discussionmentioning

confidence: 99%

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Facial swelling: an atypical presentation of cutaneous lymphoma

et al. 2016

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“…144 There have been few reports in the recent literature on cutaneous EBV+ NK/T-cell lymphoid proliferations that were different-either phenotypically or by showing an unusual clinical course-from both classic extranodal NK/T-cell lymphoma, nasal type, and hydroa vacciniformia-like lymphoma, suggesting that the spectrum of these conditions might be broader. 145,146 Blastic Plasmacytoid Dendritic Cell Neoplasm Blastic plasmacytoid dendritic cell neoplasm (BPDCN) had traditionally been included in CL classifications under designations blastic NK-cell lymphoma and agranular CD4 + CD56 + hematodermic neoplasm. This neoplasm, however, is derived from plasmacytoid dendritic cells, 147,148 hence its name BPDCN.…”

Section: Primary Cutaneous Gamma/delta T-cell Lymphomamentioning

confidence: 99%

Cutaneous Lymphomas

Kempf

Kazakov

Kerl

2014

The American Journal of Dermatopathology

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Primary cutaneous T-cell lymphomas (CTCL) represent the majority of cutaneous lymphomas (CLs) and are a spectrum of diseases with a wide variety of clinical, histological, and phenotypic features and diverse biologic behavior. This review focuses on the observations on new variants of CTCL and recent developments in deciphering the pathogenetic mechanisms, which have implication for the nosologic concepts and future classification of CLs. Variants of mycosis fungoides (MF) such as the unilesional and the papular form have been characterized in more detail. Studies analyzed the expression of CD30 and PD-1 in MF and other forms of CTCL. New variants in the group of cutaneous CD30⁺ lymphoproliferative disorders include the epidermotropic CD8⁺ variant of lymphomatoid papulosis (type D) and angiocentric lymphomatoid papulosis (type E), which histologically mimic aggressive lymphomas, and therefore may be diagnostically challenging. Cutaneous proliferations of T cell-expressing markers of follicular helper T cells (PD-1, CXCL-13, and bcl-6) display a prognostically heterogeneous group. There is an increasing spectrum of CTCL with the expression of CD8 by tumor cells, including CD8⁺ MF, CD8⁺ forms of cutaneous CD30⁺ lymphoproliferative disorders, and CD8⁺ small/medium-sized lymphoproliferations, which are not included as distinct entities in the World Health Organization-European Organization for Research and Treatment of Cancer for CLs and the World Health Organization classification. Unusual presentations and incomplete phenotypes of blastic neoplasm of plasmacytoid dendritic cells are discussed. Clinicopathologic correlation is mandatory for the diagnosis of primary CLs. Analysis of genetic and epigenetic alterations in CLs revealed new diagnostic markers and putative targets for therapy of aggressive forms of CLs.

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NK-/T-Cell Lymphoma Resembling Hydroa Vacciniforme With Positive CD4 Marker Expression

Cited by 11 publications

References 24 publications

Epstein-Barr Virus-Associated Vesiculopapular Eruption on the Face of a Patient with Natural Killer T Cell Lymphoma

Epstein-Barr Virus-Associated Vesiculopapular Eruption on the Face of a Patient with Natural Killer T Cell Lymphoma

Facial swelling: an atypical presentation of cutaneous lymphoma

Cutaneous Lymphomas

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