The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. A precise measurement of the Higgs boson couplings to bottom and top quarks is of paramount importance during the upcoming LHC runs. We present a comprehensive analysis for the Higgs production process in association with a semileptonically decaying top-quark pair and subsequent Higgs boson decay into bottom quarks. Due to the highly complex final state and large Standard Model backgrounds, measuring the signal strength in this process is known to be challenging. To maximize the sensitivity, we analyze different, statistically independent, phase space regions, where one or more of the heavy resonances are boosted. This allows us to employ jet substructure techniques, which help to reduce large tt þ X backgrounds. We find that combining several ttHðbbÞ phase space regions will allow one to measure deviations of the Standard Model signal strength of order 20% with 3 ab −1 .