NLRP3 Inflammasome: a Novel Insight into Heart Failure

Wang, Yunjiao; Li, Yanyang; Zhang, Wanqin; Yuan, Zhuo; Lv, Shichao; Zhang, Junping

doi:10.1007/s12265-022-10286-1

Cited by 7 publications

(4 citation statements)

References 85 publications

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“…24 NOD-like Receptor Pyrin Domain-containing Protein 3 (NLRP3) has been extensively studied and found to regulate the synthesis and secretion of inflammatory factors, making it crucial 25 On the other hand, studies related to SLE suggest that NLRP3 inflammatory vesicles are important in the pathogenesis of cardiovascular diseases, including HF, and inhibition of NLRP3 inflammatory vesicle-related signalling pathways is predicted to provide new interventional mediators for treating HF. 26,27 In contrast, in studies related to SLE, NLRP3 may be closely associated with the progression of Lupus Nephritis (LN), and inhibition of the activated NLRP3 inflammatory vesicle pathway may be a novel therapeutic approach for SLE and LN. 28,29 IL-17, produced mainly by activated T cells, is an inflammatory cytokine involved in the inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

Identification of Shared Immune Cells and Immune-Related Co-Disease Genes in Chronic Heart Failure and Systemic Lupus Erythematosus Based on Transcriptome Sequencing

Luo¹,

Lu²,

Yang³

et al. 2023

JIR

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Purpose The purpose was to identify shared immune cells and co-disease genes in chronic heart failure (HF) and systemic lupus erythematosus (SLE), as well as explore the potential mechanisms of action between HF and SLE. Methods A collection of peripheral blood mononuclear cells (PBMCs) from ten patients with HF and SLE and ten normal controls (NC) was used for transcriptome sequencing. Differentially expressed genes (DEGs) analysis, enrichment analysis, immune infiltration analysis, weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI) analysis, and machine learning were applied for the screening of shared immune cells and co-disease genes in HF and SLE. Gene expression analysis and correlation analysis were used to explore the potential mechanisms of co-disease genes and immune cells in HF and SLE. Results In this study, it was found that two immune cells, T cells CD4 naïve and Monocytes, displayed similar expression patterns in HF and SLE at the same time. By taking intersection of the above immune cell-associated genes with the DEGs common to both HF and SLE, four immune-associated co-disease genes, CCR7, RNASE2, RNASE3 and CXCL10, were finally identified. CCR7, as one of the four key genes, was significantly down-regulated in HF and SLE, while the rest three key genes were all significantly up-regulated in both diseases. Conclusion T cells CD4 naïve and Monocytes were first revealed as possible shared immune cells of HF and SLE, and CCR7, RNASE2, RNASE3 and CXCL10 were identified as possible key genes common to HF and SLE as well as potential biomarkers or therapeutic targets for HF and SLE.

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Section: Discussionmentioning

confidence: 99%

Identification of Shared Immune Cells and Immune-Related Co-Disease Genes in Chronic Heart Failure and Systemic Lupus Erythematosus Based on Transcriptome Sequencing

Luo¹,

Lu²,

Yang³

et al. 2023

JIR

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“…Numerous experimental studies have demonstrated that proinflammatory cytokines such as interleukin-1 (IL-1), interleukin-6, interleukin-8, and tumor necrosis factor-α (TNFα) have higher levels in individuals with HF. Patients with HF have progressive congestion that is linked to the increased levels of inflammatory mediators, [29,30] such as IL-1, interleukin-8, interleukin-6, and TNF-α. [31] Recently, it has been revealed that gut microbiota is important for both maintaining health and causing diseases.…”

Section: Enhancing the Digestion And Absorption Of Lipidsmentioning

confidence: 99%

The role of the gut microbiota and bile acids in heart failure: A review

Shi,

Wei,

Yuan

et al. 2023

Medicine

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Heart failure (HF) is the terminal manifestation of various cardiovascular diseases. Recently, accumulating evidence has demonstrated that gut microbiota are involved in the development of various cardiovascular diseases. Gut microbiota and their metabolites might play a pivotal role in the development of HF. However, previous studies have rarely described the complex role of gut microbiota and their metabolites in HF. In this review, we mainly discussed bile acids (BAs), the metabolites of gut microbiota. We explained the mechanisms by which BAs are involved in the pathogenesis of HF. We also discussed the use of gut microbiota and BAs for treating HF in Chinese medicine, highlighting the advantages of Chinese medicine in treating HF.

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“…Inflammatory responses are a major aspect of HF, involving tumor necrosis factor α (TNFα), IL-1β and IL-18. Levels of the downstream factor NLRP3 inflammatory vesicles are elevated in HF [124]. CXC motif ligand 16 (CXCL16) was identified as a novel diagnostic marker for inflammatory cardiomyopathy and HF [125].…”

Section: Inflammationmentioning

confidence: 99%

Mechanisms of action of natural small-molecule drugs in cardiovascular disease

SUN

Luo

et al. 2022

Preprint

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Cardiovascular diseases (CVDs) cause massive morbidity and mortality. In recent years, natural small-molecule therapeutics have attracted much attention for their significant efficacy. Articles have been published to study the intervention of natural drugs (including monomers, compounds, compound and neo-combinations) on one type of cardiovascular disease, but the number and variety of natural drugs included are small and insufficient, and there are no articles detailing the protective effects of different types of natural small molecule drugs on multiple cardiovascular diseases. Natural small molecule drugs have high biological activity and structural diversity, and are more likely to enter the body to exert their effects. In this article, we describe the efficacy of such drugs for anti-atherosclerosis, cardiomyocyte repair, and antagonism of ventricular remodeling, heart failure, and arrhythmias to provide an experimental basis for clinical research and identification of new therapeutic approaches.

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NLRP3 Inflammasome: a Novel Insight into Heart Failure

Cited by 7 publications

References 85 publications

Identification of Shared Immune Cells and Immune-Related Co-Disease Genes in Chronic Heart Failure and Systemic Lupus Erythematosus Based on Transcriptome Sequencing

Identification of Shared Immune Cells and Immune-Related Co-Disease Genes in Chronic Heart Failure and Systemic Lupus Erythematosus Based on Transcriptome Sequencing

The role of the gut microbiota and bile acids in heart failure: A review

Mechanisms of action of natural small-molecule drugs in cardiovascular disease

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