NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

Huang, Cong-Fa; Chen, Lei; Li, Yicun; Wu, Lei; Yu, Guang‐Tao; Zhang, Wenfeng; Sun, Zhi‐Jun

doi:10.1186/s13046-017-0589-y

Cited by 107 publications

(89 citation statements)

References 47 publications

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“…Several specific inhibitors, such as MCC950, CY‐09, arglabin, and glyburide, have been recently developed or identified to target NLRP3 inflammasome inhibition . The application of these specific NLRP3 inflammasome inhibitors has demonstrated therapeutic effects in various inflammatory disease mouse models, including models of myocardial infarction, fulminant hepatitis, steatohepatitis, lupus nephritis, atherosclerosis, Alzheimer's disease, brain injury, inflammatory bowel diseases, acute colitis, and carcinoma In allergic diseases, the application of MCC950 reduces skin and airway inflammation in mouse models of allergic dermatitis and asthma . More recently, 2 studies have shown that the targeted inhibition of NLRP3 inflammasomes with a specific inhibitor decreased IL‐1β and TH2 cytokines and inhibited HDM‐induced AHR and steroid‐resistant asthma in a mouse model .…”

Section: Resultsmentioning

confidence: 99%

NLRP3 inflammasome: A likely target for the treatment of allergic diseases

Xiao

2018

Clin Experimental Allergy

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Allergic diseases, such as asthma, rhinitis, dermatitis, conjunctivitis, and anaphylaxis, have recently become a global public health concern. According to previous studies, the NLRP3 inflammasome is a multi-protein complex known to be associated with many inflammatory conditions. In response to allergens or allergen/damage-associated molecular signals, NLRP3 changes its conformation to allow the assembly of the NLRP3 inflammasome complex and activates caspase-1, which is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines IL-1β and IL-18. Subsequently, active caspase-1 cleaves pro-IL-1 and pro-IL-18. Recently, accumulating human and mouse experimental evidence has demonstrated that the NLRP3 inflammasome, IL-1β, and IL-18 are critically involved in the development of allergic diseases. Furthermore, the application of specific NLRP3 inflammasome inhibitors has been demonstrated in animal models. Therefore, these inhibitors may represent potential therapeutic methods for the management of clinical allergic disorders. This review summarizes findings related to the NLRP3 inflammasome and its related factors and concludes that specific NLRP3 inflammasome inhibitors may be potential therapeutic agents for allergic diseases.

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Section: Resultsmentioning

confidence: 99%

NLRP3 inflammasome: A likely target for the treatment of allergic diseases

Xiao

2018

Clin Experimental Allergy

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“…Inflammatory microenviroment was believed to help the malignant transformation of normal stem or progenitor cells toward CSCs. Huang, Chen, et al () demonstrated upregulation of NLRP3 inflammasome was associated with CSCs self‐renewal activation in head and neck squamous cell carcinoma (HNSCC). Higher level of systemic Inflammation Response Index (SIRI) was associated with CD44 + CSCs scores in gastric cancer patients and predict unfavorable clinical outcomes (Li, Lan, et al, ).…”

Section: Nf‐κb Stimulated Chronic Inflammation Promotes Cancer Stem Cmentioning

confidence: 99%

Rediscovery of NF‐κB signaling in nasopharyngeal carcinoma: How genetic defects of NF‐κB pathway interplay with EBV in driving oncogenesis?

Man

Cai

et al. 2018

Journal Cellular Physiology

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Nasopharyngeal carcinoma (NPC) is a unique EBV-associated subtype of head and neck cancer, which has the highest incidence in Southern China and eastern South Asia. The interaction between genetic risk factors and environmental challenge, have been considered to contribute to the development of nasopharyngeal carcinogenesis. Constitutive activation of NF-κB signaling has been seen in NPC tissues and is associated with unfavorable prognosis. Recently, several whole exome sequencing study consistently revealed that high frequency mutations of NF-κB pathway negative regulators is common in nasopharyngeal carcinoma, which reinforce the importance of NF-κB driving oncogenesis. This review focuses on the current state of research in role of NF-κB in NPC carcinogenesis. We summarized the newly identified loss of function (LOF) mutations on NF-κB negative regulators leading to it's activation bypass LMP-1 stimulation. We discussed the critical role of NF-κB activation in immortalization and transformation of nasopharygeal epithelium. We also depicted how NF-κB signaling mediated chronic inflammation contribute to persistent EBV infection, immune evasion of EBV infected cells, metabolic reprogramming, and cancer stem cells (CSCs) formation in NPC. Lastly, we discussed the clinical resonance of targeting NF-κB for NPC precise therapy.

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“…This meta-analysis on the prognostic value of in ammasome molecules included 14 studies with a total of 677 patients. The expression of in ammasome molecules was found to be a controversial prognostic factor for the OS, DFS, and RFS of HNC patients (34)(35)(36)(37)(38). Although the current view is that in ammasome molecules may be important predictors of a poor prognosis in HNC (36), we found that higher expression of in ammasome molecules was associated with longer RFS of HNC patients.…”

Section: Sensitivity Analysis and Publication Biasmentioning

confidence: 55%

Prognostic Value of Inflammasomes in Head and Neck Carcinoma: A Meta-analysis

Jia

Chen

et al. 2020

Preprint

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Background: Inflammasomes play important roles in responding to insults, triggering inflammation. Nonetheless, their correlation with the prognosis of the head and neck carcinoma (HNC) patients remains controversial. Methods: In this meta-analysis, we searched 5 inflammasomes in PubMed, Embase and Web of Science databases and included 14 prospective studies with 677 patients. There were two molecules, pyrin domain containing 3 (NLRP3) and Absent In Melanoma 2 (AIM2) satisfied the criteria for further analysis. Results: Higher expression of both NLRP3 and AIM2 was correlated with longer recurrence-free survival of HNC patients (P < 0.001). And higher level of AIM2 expression was associated with better overall survival in HNC patients (P < 0.001). Conclusions: Although publication bias potentially existed, NLRP3 and AIM2 are possible prognostic predictors in HNC patients.

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NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

Cited by 107 publications

References 47 publications

NLRP3 inflammasome: A likely target for the treatment of allergic diseases

NLRP3 inflammasome: A likely target for the treatment of allergic diseases

Rediscovery of NF‐κB signaling in nasopharyngeal carcinoma: How genetic defects of NF‐κB pathway interplay with EBV in driving oncogenesis?

Prognostic Value of Inflammasomes in Head and Neck Carcinoma: A Meta-analysis

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