NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases

Abstract

Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.

C-Reactive Protein Signaling Pathways in Tumor Progression

“…CRP increased the expression of pro-IL-1β and NLRP3 through the FcγRs/NF-κB pathway in endothelial cells. It also promoted NLRP3 inflammasome activation and IL-1β maturation by upregulating ROS levels, purinergic receptor signaling, and the activation of cysteine proteases ( Bian et al ., 2019 ; Prakash et al ., 2023 ). These findings indicate an association between elevated levels of CRP and NLRP3 inflammasomes in atherosclerosis.…”