2022
DOI: 10.3389/fimmu.2022.978190
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NLRP3 inflammasome in digestive diseases: From mechanism to therapy

Abstract: Digestive system diseases remain a formidable challenge to human health. NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most characteristic multimeric protein complex and is involved in a wide range of digestive diseases as intracellular innate immune sensors. It has emerged as a research hotspot in recent years. In this context, we provide a comprehensive review of NLRP3 inflammasome priming and activation in the pathogenesis of digestive diseases, including clinical and precli… Show more

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Cited by 11 publications
(3 citation statements)
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“…Digestive system diseases, including inflammatory bowel disease (IBD), diverticulitis, colorectal cancer, and liver diseases, arise primarily through the interplay of genetic and environmental influences. There conditions pose a formidable challenge to human health and have become a growing global burden [ 155 , 156 ]. Oxidative stress is a major contributor to gastrointestinal mucosal diseases, with the overproduction of ROSs implicated in the development of these conditions [ 157 , 158 ].…”
Section: Research Progress In Gpx3 and Non-neoplastic Diseasesmentioning
confidence: 99%
“…Digestive system diseases, including inflammatory bowel disease (IBD), diverticulitis, colorectal cancer, and liver diseases, arise primarily through the interplay of genetic and environmental influences. There conditions pose a formidable challenge to human health and have become a growing global burden [ 155 , 156 ]. Oxidative stress is a major contributor to gastrointestinal mucosal diseases, with the overproduction of ROSs implicated in the development of these conditions [ 157 , 158 ].…”
Section: Research Progress In Gpx3 and Non-neoplastic Diseasesmentioning
confidence: 99%
“…NLRP3 inflammasome formation is believed to be pro-tumorigenic with regards to PDAC (reviewed in [5]). PDAC tumor cells can produce IL-1β through NLRP3 inflammasome activation [18], and this is essential to the establishment of the tumor microenvironment [19]. However, the IL-1β protein is often undetected in PDAC cell lines grown in vitro and as organoids but robustly produced by primary PDAC tumors [17].…”
Section: Introductionmentioning
confidence: 99%
“…Despite its protective function, inflammasome activation must be tightly regulated, since, if prolonged, it could aggravate the outcome of several inflammation-driven diseases, such as cryopyrin-associated periodic syndrome, arthritis, atherosclerosis, type 2 diabetes, Alzheimer's disease, inflammatory bowel diseases (IBDs), including Crohn’s disease (CD), ulcerative colitis (UC), and cancer [ 8 ], whose onset and development is mostly a consequence of multiple risk factors. Among inflammasomes, the NLRP3 pathway is the best studied today, featuring both protective and pathogenic abilities within the gastrointestinal (GI) tract [ 9 ]. In this review we aim to summarize the current knowledge of the patho-physiological aspects of NLRP3 inflammasome activation in the GI tract and the potential therapeutic approaches considered nowadays as alternatives to conventional protocols in patients with inflammatory-driven GI disorders, laying particular emphasis on IBD and cancer.…”
Section: Introductionmentioning
confidence: 99%