nm23 expression in human breast cancer: correlation with cell proliferation (S-phase) as observed with a double-labeling immunocytochemical-autoradiographic technique.

Nm23 Gene Product Expression in Invasive Breast Cancer

“…Some other investigators found no correlation between nm23-H1 expression and the rate of relapse, or prognostic signi cance in node-negative breast cancer patients or in overall survival (29). There are studies con rming only positive correlation with histological grade (30), there isn't any signi cant association with the number of positive axillary lymph nodes but there is some PgR positivity, which might be responsible for the favorable outcome in certain groups of breast cancer patients (31), higher morbidity in metallothionein »:nm23-context (32); using a double-labeling, immunocytochemical-autoradiographic technique, there was no correlation between nm23 and cell proliferation (33).…”