NMDA receptor activation stimulates transcription-independent rapid wnt5a protein synthesis via the MAPK signaling pathway

Li, Yichen; Li, Bei; Wan, Xuejin; Zhang, Wei; Zhong, Ling; Tang, Shao-Jun

doi:10.1186/1756-6606-5-1

Cited by 68 publications

(75 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1G). This discrepancy is probably due to NMDAstimulated rapid translation from pre-existing mRNA, as suggested by previous studies (Ouyang et al, 1999;Li et al, 2012). Also, the ADAM10 protein increase is more transient that the increase of ADAM10 mRNA (Fig.…”

Section: Nmdar Activation Increases Adam10 Proteinmentioning

confidence: 54%

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

Wan

Li³

et al. 2012

J. Neurosci.

View full text Add to dashboard Cite

A disintegrin and metalloproteinase 10 (ADAM10) is the constitutive ␣-secretase that governs the nonamyloidogenic pathway of ␤-amyloid precursor protein processing and is an attractive drug target for treating Alzheimer's disease. To date, little is known about the mechanism by which ADAM10 is regulated in neurons. Using mouse primary cortical neurons, we show here that NMDA receptor (NMDAR) activation led to upregulation of the genes encoding ADAM10 and ␤-catenin proteins. Interestingly, the ADAM10 upregulation was abolished by inhibitors of Wnt/␤-catenin signaling. Conversely, activation of the Wnt/␤-catenin signaling pathway by recombinant Wnt3a stimulated ADAM10 expression. We further showed that both the NMDAR-and Wnt3a-induced ADAM10 upregulation was blocked by ERK inhibitors. We suggest that the NMDARs control ADAM10 expression via a Wnt/MAPK signaling pathway.

show abstract

Section: Nmdar Activation Increases Adam10 Proteinmentioning

confidence: 54%

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

Wan

Li³

et al. 2012

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…mRNA, messenger RNA; d, days; GSK-3b, glycogen synthase kinase 3 beta; LEF1, lymphoid enhancer-binding factor-1. by synaptic activity [54][55][56] and that the b-catenin signaling pathway played a key role in synaptic assembly, remodeling, and plasticity. [57][58][59] Moreover, our results highlight a differential pattern of expression of Fz receptors by the different cell types residing in the spinal cord, as shown for Fz1 in neurons and oligodendrocytes and Fz4 in astrocytes, suggestive for them still to unravel cellspecific patterns of Wnt receptors that might be key for the neuronglia interplay and, as a result, the modulation of neural transmission in both physiological and pathological conditions.…”

Section: Discussionmentioning

confidence: 99%

Wnts Are Expressed in the Spinal Cord of Adult Mice and Are Differentially Induced after Injury

González-Fernández

Fernández-Martos

Shields

et al. 2014

Journal of Neurotrauma

View full text Add to dashboard Cite

The Wnt family of proteins plays key roles during central nervous system development and has been involved in several neuropathologies during adulthood, including spinal cord injury (SCI). However, Wnts expression knowledge is relatively limited during adult stages. Here, we sought to define the Wnt family expression pattern after SCI in adult mice by using quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC). Under physiological conditions, the messenger RNAs (mRNAs) of most Wnt ligands, inhibitors, receptors, and coreceptors are constitutively expressed in healthy adult mice. After dorsal hemisection, we found significant time-dependent variations, with a prominent upregulation of Wnt inhibitory factor 1 (Wif1). IHC against Frizzled (Fz) 1 and Fz4, as representatives of late and acute upregulated receptors, showed a differential expression in the uninjured spinal cord of Fz1 by neurons and oligodendrocytes and Fz4 by astrocytes. After injury, both receptors were maintained in the same type of cells. Finally, by using BATgal reporter mice, our results revealed active b-catenin signaling in neurons of the dorsal horn and cells of the central canal of uninjured spinal cords, besides a lack of additional SCI-induced activation.In conclusion, we demonstrate Wnt expression in the adult spinal cord of mice that is modulated by SCI, which differs from that previously described in rats. Further, Fz receptors are differentially expressed by neurons and glial cells, suggestive for cell-specific patterns and thus diverse physiological roles. Further studies will help toward in-depth characterization of the role of all Wnt factors and receptors described and eventually allow for the design of novel therapies.

show abstract

“…Li et al reported that NMDAR activation induces rapid Wnt5a protein synthesis and secretion (43). Interestingly, this NMDAR activation-stimulated Wnt5a synthesis is not dependent on transcription, and thus is a result of stimulating translation from pre-existing Wnt5a mRNA.…”

Section: Synaptic Activity-regulated Wnt Signalingmentioning

confidence: 99%

Synaptic Activity-Regulated Wnt Signaling in Synaptic Plasticity, Glial Function and Chronic Pain

Tang¹

2014

CNSNDDT

Self Cite

View full text Add to dashboard Cite

Wnt signaling pathways are master regulatory networks in a variety of developmental and oncogenic processes. In the nervous system, Wnt signaling pathways are known to regulate neuronal morphogenesis and synaptic differentiation. Aberrant Wnt signaling is implicated in various neurological diseases. Recent studies have revealed that the activity of Wnt signaling pathways is critically controlled by synaptic activity. The activity-regulated Wnt signaling plays an important role in the expression of synaptic plasticity and memory formation. Dysregulation of the activity-regulated Wnt signaling may have a significant impact on the function of the nervous system. In this article, we will review the identified mechanisms by which synaptic activity controls Wnt signaling in neurons and the neurological functions of the activity-regulated Wnt signaling under normal and specific disease conditions. In particular, we will discuss the role of Wnt signaling in the pathogenesis of chronic pain.

show abstract

NMDA receptor activation stimulates transcription-independent rapid wnt5a protein synthesis via the MAPK signaling pathway

Cited by 68 publications

References 40 publications

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway

Wnts Are Expressed in the Spinal Cord of Adult Mice and Are Differentially Induced after Injury

Synaptic Activity-Regulated Wnt Signaling in Synaptic Plasticity, Glial Function and Chronic Pain

Contact Info

Product

Resources

About