NMDA Receptor Complex Blockade by Oral Administration of Magnesium: Comparison with MK-801

Decollogne, Stéphanie

doi:10.1016/s0091-3057(96)00555-2

Cited by 74 publications

(44 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present study, where depressive-like behaviour is observed in the MgD mice, is thus in line with a previous report, demonstrating depressive-like behaviour following 3 weeks on dietary MgD (27). Supporting the observed depressive-like phenotype in MgD fed mice, studies have shown that administration of Mg elevates the serum levels of Mg, and reduce time spent immobile in the FST, suggesting Mg to act as an antidepressant in the FST (34,35). The importance of these findings in translational setting is underlined by several studies demonstrating a clear connection between the level of Mg and affective symptomatology (36).…”

Section: Discussionsupporting

confidence: 93%

“…Interestingly, blocking the NMDAr by antagonists has shown increased NMDAr/α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor density in hippocampus and to simulate antidepressant effect (41) as well as the co-administration of Mg (34,43). Mg depletion may also play a role in the monoaminergic systems as Mg is a cofactor in activating tryptophan, a precursor in dopamine and serotonin synthesis (26,44).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour

Winther

Jørgensen

Elfving

et al. 2015

Acta Neuropsychiatr.

View full text Add to dashboard Cite

ObjectiveGut microbiota (GM) has previously been associated with alterations in rodent behaviour, and since the GM is affected by the diet, the composition of the diet may be an important factor contributing to behavioural changes. Interestingly, a magnesium restricted diet has been shown to induce anxiety and depressive-like behaviour in humans and rodents, and it could be suggested that magnesium deficiency may mediate the effects through an altered GM.MethodsThe present study therefore fed C57BL/6 mice with a standard diet or a magnesium deficient diet (MgD) for 6 weeks, followed by behavioural testing in the forced swim test (FST) to evaluate depressive-like behaviour. An intraperitoneal glucose tolerance test (GTT) was performed 2 day after the FST to assess metabolic alterations. Neuroinflammatory markers were analysed from hippocampus. GM composition was analysed and correlated to the behaviour and hippocampal markers.ResultsIt was found that mice exposed to MgD for 6 weeks were more immobile than control mice in the FST, suggesting an increased depressive-like behaviour. No significant difference was detected in the GTT. GM composition correlated positively with the behaviour of undisturbed C57BL/6 mice, feeding MgD diet altered the microbial composition. The altered GM correlated positively to the hippocampal interleukin-6.ConclusionIn conclusion, we hypothesise that imbalances of the microbiota–gut–brain axis induced by consuming a MgD diet, contributes to the development of depressive-like behaviour.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour

Winther

Jørgensen

Elfving

et al. 2015

Acta Neuropsychiatr.

View full text Add to dashboard Cite

show abstract

“…Glavni mehanizam kojim magnezijum ostvaruje svoje efekte u centralnom nervnom sistemu (CNS) zasniva se na interakciji sa glutamatergičkim neurotransmiterskim sistemom, odnosno blokadi NMDA receptora (8,9).…”

Section: Magnezijum I Njegova Uloga U Organizmuunclassified

Role of magnesium in depression?

Petrović¹,

Pešić²,

Popović³

et al. 2014

Arh farmaciju

View full text Add to dashboard Cite

Magnezijum ima značajnu fiziološku ulogu u humanom organizmu i neophodan je za mnoge procese, uključujući: transmembransko kretanje jona, aktivnost neurona, oslobađanje neurotransmitera, regulaciju adenilat ciklaze i vezivanje pojedinih hormona za receptore. U centralnom nervnom sistemu magnezijum blokira aktivnost NMDA receptora, a deficit magnezijuma dovodi do prekomerne aktivacije NMDA receptora, što za posledicu može imati oštećenja neurona i neurološke disfunkcije i u krajnjoj liniji, može se manifestovati razvojem velike depresije. Brojna pretklinička i klinička ispitivanja potvrđuju da magnezijum utiče na nekoliko sistema uključenih u razvoj depresije. Sa druge strane, oko 40% pacijenata pokazuje rezistenciju na tretman standardnim antidepresivima, kojima se pripisuju i brojni neprijatni neželjeni efekti. Iako je prvi pozitivan učinak magnezijuma kod pacijenata koji pate od agitirane depresije prikazan još 1921, nažalost, samo mali broj studija koje govore u prilog efikasnosti magnezijuma u tretmanu depresije je publikovan tokom proteklih decenija, uključujući jedno randomizovano kliničko ispitivanje koje je pokazalo podjednaku efikasnost magnezijuma i imipramina kod starijih depresivnih pacijenata koji boluju od dijabetesa. Iako je neophodno sprovesti veći broj kliničkih ispitivanja i proširiti ovo polje istraživanja u cilju potvrđivanja njegove efikasnosti, usled svoje bezbednosti, magnezijum bi se potencijalno mogao uvesti kao dodatni tretman u lečenju depresije rezistentne na terapiju.

show abstract

“…Apomorphine--and L--amphetamine mediated behaviour was suppressed by Mg deficiency, suggesting that Mg is an important factor for the stimulatory action of catecholamines, possibly at the postsynaptic site. In the forced swim test, a screening test for possible antidepressive potency of substances, Mg reduced immobility similar to the nor--adrenaline reuptake inhibitor imipramine (Decollogne et al, 1997). Compared to control mice fed a normal diet, mice receiving a low Mg diet (10% of daily requirement) for several weeks displayed increased immobility time in the forced swim test, indicating enhanced depression--like behaviour.…”

Section: Neurological Function Of Magnesiummentioning

confidence: 97%

“…At normal neuronal resting membrane potentials, pores of the NMDA glutamate--gated ion channels are blocked by Mg 2+ ions (Bear et al, 2001;Mark et al, 2001;Kandel et al, 1995;McMenimen, 2006). The ion channel of the NMDA receptor complex is subject to voltage--dependent regulation by Mg 2+ ions (Mark et al, 2001;Alberts et al, 2002;Decollogne et al, 1997). Importantly, different types of NMDA receptors exist, on the basis of their constitution subunits.…”

Section: Neurological Function Of Magnesiummentioning

confidence: 99%

Magnesium in the Central Nervous System

Turner

Vink

New Perspectives in Magnesium Research

View full text Add to dashboard Cite

NMDA Receptor Complex Blockade by Oral Administration of Magnesium: Comparison with MK-801

Cited by 74 publications

References 37 publications

Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour

Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour

Role of magnesium in depression?

Magnesium in the Central Nervous System

Contact Info

Product

Resources

About