2002
DOI: 10.1152/jn.00599.2001
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NMDA Receptor-Mediated Currents in Rat Cerebellar Granule and Unipolar Brush Cells

Abstract: verse Slater. NMDA receptor-mediated currents in rat cerebellar granule and unipolar brush cells. J Neurophysiol 87: 1948 -1959, 2002; 10.1152/jn.00599.2001. The properties of N-methyl-D-aspartate (NMDA) receptor-mediated currents at the giant cerebellar mossyfiber unipolar brush cell (UBC) synapse were compared with those of adjacent granule cells using patch-clamp recording methods in thin slices of rat cerebellar nodulus. In UBCs, NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) decayed as a… Show more

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Cited by 22 publications
(15 citation statements)
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“…The low conductance and slow deactivation time we have observed for NMDARs in polychromatic erythroblasts were shown to be characteristic for the receptor formed by the GluN2C/D and GluN3B subunits (49). Currents mediated by the NMDAR in proerythroblasts showed no plateau phase as it was reported for the NMDAR currents in neuronal cells (4). These findings indicate that an atypical subunit composition and functional pattern of NMDAR in erythroid cells resemble the properties of the receptors described for other nonneuronal tissues (7, 28, 39).…”
Section: Discussionsupporting
confidence: 57%
“…The low conductance and slow deactivation time we have observed for NMDARs in polychromatic erythroblasts were shown to be characteristic for the receptor formed by the GluN2C/D and GluN3B subunits (49). Currents mediated by the NMDAR in proerythroblasts showed no plateau phase as it was reported for the NMDAR currents in neuronal cells (4). These findings indicate that an atypical subunit composition and functional pattern of NMDAR in erythroid cells resemble the properties of the receptors described for other nonneuronal tissues (7, 28, 39).…”
Section: Discussionsupporting
confidence: 57%
“…However, the initial studies of mossy fiber-UBC synaptic transmission (Rossi et al, 1995; Kinney et al, 1997; Billups et al, 2002) were done prior to subtype characterization, and only the ON UBC was described. Since then, one other study of cerebellar UBCs investigated synaptic kinetics, again only describing ON UBCs (van Dorp and de Zeeuw, 2014).…”
Section: Resultsmentioning
confidence: 99%
“…As is known, cable properties of a dendritic arborization are largely determined by its geometry and span (Vetter et al, 2001). In particular, short and thick dendrites guarantee stable and efficient spike propagation to the soma, while a high spatial density of terminal arborization together with a long primary dendrite (as in the case of long-dendrite UBCs) impedes spike spatial summation and propagation (Kinney et al, 1997;Billups et al, 2002). Given the above, elaborated terminal arborization of dolphin UBCs suggests their high integrative capacities, and variation in primary dendrite length between potential UBC types may reflect differences in their cable properties.…”
Section: Discussionmentioning
confidence: 99%