NMDAR antibody encephalitis and fluctuating catatonia

Kar, Nilamadhab; Kumar, Manish; Barreto, Socorro

doi:10.1002/pnp.473

Cited by 2 publications

(1 citation statement)

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“…11 Catatonia was noted in various inflammatory brain diseases 12,13 and highly prevalent in psychiatric patients who were positive for N-methyl-d-aspartate (NMDA) receptor antibodies. 14,15 A recent review by Rogers and colleagues considered immune activation and downstream glutamatergic or GABA-ergic dysregulation played key roles in the pathogenesis of catatonia, as it occurs in various autoimmune conditions. 16 Myelin-producing oligodendrocytes and low-grade neuroinflammation have been implicated in the pathogenesis of catatonia.…”

Section: Introductionmentioning

confidence: 99%

Higher Serum C-Reactive Protein Levels in Catatonic Patients: A Comparison to Non-catatonic Patients and Healthy Controls

Zhou

Lee

Zhang

et al. 2020

Schizophrenia Bulletin

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Catatonia is a psychomotor syndrome defined by a constellation of predominantly motor symptoms. The aim of the present study was to determine whether recently admitted psychiatric patients with catatonia exhibited higher serum C-reactive protein (hs-CRP) levels compared to non-catatonic psychiatric patients and healthy controls (HCs). Recently admitted psychiatric patients were screened and evaluated for the catatonia syndrome using the Bush-Francis Catatonia Rating Scale and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). The study sample was formed by 150 individuals (39 male and 111 female), including 51 catatonic patients, 55 non-catatonic patients, and 44 HCs. Serum hs-CRP levels were processed with the enzyme-linked immunosorbent assay. Serum levels of creatine kinase (CK), adrenocorticotropic hormone (ACTH), immunoglobulin G (IgG), complement component 3 (C3), and complement component 4 (C4) were also determined. There was a significantly higher percentage of patients with high inflammatory levels (hs-CRP > 3000ng/ml) in the catatonic (43.1%) than in the non-catatonic (14.5%) or HCs group (9.1%) (χ 2 =18.9, P < .001). Logistic regression showed that catatonic patients had significantly higher hs-CRP levels compared to non-catatonic patients even after controlling for other clinical and laboratory variables (OR = 3.52, P = .015, 95% CI 1.28–9.79). Multiple linear regression analysis revealed that log-transformed hs-CRP was independently predicted by body mass index and log-transformed C4, ACTH, and Cortisol in catatonic patients. Findings of the present study suggest that catatonia is specifically linked to a higher level of systemic inflammation, not merely attributable to the overall psychopathology, or alterations in the stress level and complement system.

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Section: Introductionmentioning

confidence: 99%