This ethnobotanical study highlights the significant knowledge of the Maya Yucatecan healers about medicinal plants used to treat skin diseases and the importance of studying the ancient knowledge inherited from generation to generation. Historically, the Maya people have relied on the use of medicinal plants to treat various ailments, including skin diseases. The study focuses on identifying the plants that have been traditionally employed for these purposes. By comparing historical sources with contemporary ethnobotanical data gathered from the field, this research uncovers the evolving patterns of plant usage over time. It also underscores the significance of considering sociopolitical circumstances in understanding changes in local knowledge. The data indicated that Rutaceae, Euphorbiaceae, Lamiaceae, and Asteraceae were the most represented families. The ethnohistoric record also showed gaps linked to the local knowledge developed by the Mayans over time. The principal component analysis technique applied to our ethnobotanical data simplifies the complexity of information on the use of medicinal flora to treat skin conditions, resulting in a new predictive model for pooling herbal knowledge. Correlations indicated that more than 50% of the listed species are used to treat fungal infections. This historical perspective enriches our understanding of the dynamic relationship between the Maya people and their use of medicinal plants for skin-related ailments.