NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus

Fyfe, C. A.; Grondey, H.; Blazek-Welsh, Almira I.; Chopra, Sham K; Fahie, Brian J

doi:10.1016/s0168-3659(00)00237-6

Cited by 57 publications

(26 citation statements)

References 8 publications

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“…A specially designed, MR compatible, flow-through cell combined with MRI probe-head for HBS systems investigation was used [2]. In the cell the HBS capsule was kept in a horizontal position in the centre of the RF coil, and was oriented along the direction of B 0 field.…”

Section: Methodsmentioning

confidence: 99%

Magnetic Resonance Imaging Analysis of Moving Fronts in Floating Dosage Forms

et al. 2005

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Section: Methodsmentioning

confidence: 99%

Magnetic Resonance Imaging Analysis of Moving Fronts in Floating Dosage Forms

et al. 2005

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“…[30][31][32][33] MRI has also been used to correlate drug release profiles with dissolution events for the tablet being examined ex situ 34 and in situ in the dissolution equipment. 35,36 In addition, magnetic markers have been used to monitor the location and transit velocities of tablets when in vivo and correlated to dissolution measured by plasma concentrations. 37,38 Low-field MRI using permanent magnets is an emerging field for studying dissolution.…”

Section: Introductionmentioning

confidence: 99%

MRI Studies of the Hydrodynamics in a USP 4 Dissolution Testing Cell

Shiko

Gladden

Sederman

et al. 2011

Journal of Pharmaceutical Sciences

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“…By acquiring multiple readings per second, a visualization of the flow can be constructed. Use of both NMR and MRI-based methods to investigate the hydration, physical changes, and drug release from drug delivery systems in the USP 4 flowthrough apparatus have been described (17)(18)(19).…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Characterization and Simulation of Hydrodynamics in the Paddle, Basket and Flow-Through Dissolution Testing Apparatuses - A Review

Todaro¹,

Pearsons²,

Grove³

et al. 2017

Dissolution Technol.

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Fluid velocity local to the dissolving surface will affect the dissolution rate. It is difficult to anticipate what local fluid velocities are present within compendial dissolution apparatuses from set flow rates or stirring rates. A range of qualitative and quantitative velocimetric techniques are available to assess and characterize hydrodynamics. These methods are frequently used in combination with computational fluid dynamics simulations to characterize and simulate hydrodynamics. Dosage form location and motion varies between apparatuses, and the presence of the dosage form itself can impact local hydrodynamics. Each apparatus described has identified hydrodynamic features which may also vary with agitation rate. This review describes the methods used to simulate and characterize hydrodynamics and summarizes some of the main findings from studies investigating hydrodynamics in the paddle, basket, and flowthrough dissolution apparatuses.

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NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus

Cited by 57 publications

References 8 publications

Magnetic Resonance Imaging Analysis of Moving Fronts in Floating Dosage Forms

Magnetic Resonance Imaging Analysis of Moving Fronts in Floating Dosage Forms

MRI Studies of the Hydrodynamics in a USP 4 Dissolution Testing Cell

Characterization and Simulation of Hydrodynamics in the Paddle, Basket and Flow-Through Dissolution Testing Apparatuses - A Review

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