NMR metabolomic of frontal cortex extracts: First study comparing two neurodegenerative diseases, Alzheimer disease and amyotrophic lateral sclerosis

Botosoa, Eliot Patrick; Zhu, Mingxin; Marbeuf-Gueye, Carole; Triba, Mohamed N.; Dutheil, Fabien; Duyckaerts, Charles; Beaune, Philippe; Loriot, M.A.; Moyec, Laurence Le

doi:10.1016/j.irbm.2012.08.002

Cited by 19 publications

(26 citation statements)

References 35 publications

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“…After multivariate statistical analysis of the 8 AD and the 11 ALS samples, a high score in the statistical parameters of OPLS was obtained with the exclusion of one AD sample. Increased concentration of branched amino acids, alanine, acetate, glutamine, glutamate and glycerophosphocholine in AD patients was observed when compared to ALS [88].…”

Section: Metabolomics and Ad In Post-mortem Brain Tissuementioning

confidence: 91%

“…The broad information obtained by metabolic fingerprinting approach make it the most attractive and suitable strategy for biomarker discovery [85], while at the same time, represents the most challenging and time-consuming approach in Metabolomics. In AD research, the obtaining of metabolic fingerprints is a recent practice by using both NMR [87][88][89] and MS-based [90][91][92][93][94] techniques.…”

Section: Metabolomics In Admentioning

confidence: 99%

“…Polar biomarkers have also been investigated by NMR [88] in post-mortem BT samples. These samples were treated with perchloric acid and metabolic extracts were analyzed to compare AD with amyotrophic lateral sclerosis (ALS) [88].…”

Section: Metabolomics and Ad In Post-mortem Brain Tissuementioning

confidence: 99%

“…These samples were treated with perchloric acid and metabolic extracts were analyzed to compare AD with amyotrophic lateral sclerosis (ALS) [88]. After multivariate statistical analysis of the 8 AD and the 11 ALS samples, a high score in the statistical parameters of OPLS was obtained with the exclusion of one AD sample.…”

Section: Metabolomics and Ad In Post-mortem Brain Tissuementioning

confidence: 99%

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Metabolomics in the Study of Alzheimer's Disease

Ibáñez

Valdés

García‐Cañas

et al. 2014

Comprehensive Analytical Chemistry

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With an increasing aging population, Alzheimer's disease (AD) has become a social and economic problem to societies worldwide, affecting millions of people. However, pathophysiological events associated with AD are not well elucidated yet and current definitive diagnosis is only obtained after death through examination of brain tissue. In the last years, Metabolomics has been demonstrated to provide deep insights into the full complexity of the disease phenotype and has been established as a promising approach to provide disease-specific metabolite signatures. The incipient application of Metabolomics may potentially contribute in the elucidation of AD physiopathological processes and ideally may offer therapeutic/preventing mechanisms to slow or reverse AD progress. In this chapter non-targeted metabolomics approaches applied to AD investigation are described.

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Section: Metabolomics and Ad In Post-mortem Brain Tissuementioning

confidence: 91%

Section: Metabolomics In Admentioning

confidence: 99%

Section: Metabolomics and Ad In Post-mortem Brain Tissuementioning

confidence: 99%

Section: Metabolomics and Ad In Post-mortem Brain Tissuementioning

confidence: 99%

See 2 more Smart Citations

Metabolomics in the Study of Alzheimer's Disease

Ibáñez

Valdés

García‐Cañas

et al. 2014

Comprehensive Analytical Chemistry

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show abstract

“…Most of these studies have been performed in biofluids because of the difficult availability of human brain tissue. Thus, only a few preliminary studies have been previously reported in this subject [12][13][14], demonstrating the potential of this approach.…”

Section: Introductionmentioning

confidence: 99%

Brain Metabolomics Study on the Protective Effects of Ginsenosides Rg1 and Rb1 in an Alzheimer’s Disease Mouse Model

Li¹

2015

Pharm Anal Chem

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Targeted metabolomics study of early pathological features in hippocampus of triple transgenic Alzheimer’s disease male mice

Zhao

Chen

Iqbal

et al. 2020

J of Neuroscience Research

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Alzheimer's disease (AD) is a serious neurodegenerative disease in people of age 65 or above. The detailed etiology and pathogenesis of AD have not been elucidated yet. In this study, the hippocampi of 2‐ and 6‐month‐old triple transgenic Alzheimer's disease male mice and age–sex‐matched wild‐type (WT) mice were analyzed by using targeted metabolomics approach. Compared with WT mice, 24 and 60 metabolites were found with significant differences in 2‐ and 6‐month‐old AD mice. Among these, 14 metabolites were found common while 10 metabolites showed consistent variable trends in both groups. These differential metabolites are found associated with amino acid, lipid, vitamin, nucleotide‐related base, neurotransmitter and energy metabolisms, and oxidative stress. The results suggest that these differential metabolites might play a critical role in AD pathophysiology, and may serve as potential biomarkers for AD. Moreover, the results highlight the involvement of abnormal purine, pyrimidine, arginine, and proline metabolism, along with glycerophospholipid metabolism in early pathology of AD. For the first time, several differential metabolites are found to be associated with AD in this study. Targeted metabolomics can be used for rapid and accurate quantitative analysis of specific target metabolites associated with AD.

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NMR metabolomic of frontal cortex extracts: First study comparing two neurodegenerative diseases, Alzheimer disease and amyotrophic lateral sclerosis

Cited by 19 publications

References 35 publications

Metabolomics in the Study of Alzheimer's Disease

Metabolomics in the Study of Alzheimer's Disease

Brain Metabolomics Study on the Protective Effects of Ginsenosides Rg1 and Rb1 in an Alzheimer’s Disease Mouse Model

Targeted metabolomics study of early pathological features in hippocampus of triple transgenic Alzheimer’s disease male mice

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