NMR spectroscopy in pharmaceutical analysis III. NMR spectra of13C-aminoglycoside antibiotics kanamycin and amikacin in acidic and basic media

Chernyshev, A. I.; Kartashov, V. S.; Арзамасцев, А. П.; Esipov, S. E.

doi:10.1007/bf00764426

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2021

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“…1(C)). [38][39][40] After immobilization of amikacin, the signal of the carbon atom 4 00 with a chemical shift of 29.97 ppm (Fig. 1(C)) shifts to the region of 31.71 ppm (Fig.…”

Section: Resultsmentioning

confidence: 99%

Immobilization of amikacin on dextran: biocomposite materials that release an antibiotic in the presence of bacterial dextranase

Dyatlov

Seregina

Luss

et al. 2021

Polymer International

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The immobilization of a broad-spectrum antibiotic amikacin on macromolecules of dextran previously modified with epichlorohydrin is described. It is shown that the release of amikacin is observed only in the presence of dextranase, which is produced by bacteria. For the first time, biocomposite materials based on the Glisson capsule of the liver and the pericardium, containing a layer of grafted dextran acting as a carrier of amikacin and capable of releasing amikacin derivatives that have antibacterial activity in the case of infection, have been developed. It was found that the release rate of amikacin derivatives formed in the presence of dextranase is determined by diffusion and is inversely proportional to the squared thickness of the dextrancontaining layer on the surface of biocomposite materials.

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“…1(C)). [38][39][40] After immobilization of amikacin, the signal of the carbon atom 4 00 with a chemical shift of 29.97 ppm (Fig. 1(C)) shifts to the region of 31.71 ppm (Fig.…”

Section: Resultsmentioning

confidence: 99%