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Bikashvili, Tamar; Shukakidze, A; Кикнадзе, Г. И.

doi:10.1023/a:1010432527359

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…These observations come in agreement with the findings of previous studies that showed degenerated neurons with disorganization of cytoplasmic components and swelling of mitochondria in Mn-treated mice [ 6 ]. These findings were also similar to those observed by other investigators in the neurons of rat cerebral cortex after treatment with Mn, including cytoplasmic vacuolation, swollen mitochondria, dilated RER and Golgi apparatus as well as accumulated lysosomes [ 40 ].…”

Section: Discussionsupporting

confidence: 92%

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The effect of manganese on the olfactory bulb of adult male albino rat and the role of meloxicam: A histological and immunohistochemical study

Mousa

Shehab

2015

J Microsc Ultrastruct

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Manganese (Mn) is an essential metal commonly found in the environment and is used for industrial purposes. Exposure to excessively high Mn levels may induce neurotoxicity referred to as manganism. This work was conducted to study the effect of manganese on the olfactory bulb of adult male albino rat and the possible protective role of meloxicam. Forty adult male albino rats were equally divided into four groups: control group, meloxicam-treated group (5 mg/kg/day orally for 4 weeks), MnCl2-treated group (10 mg/kg/day orally for 4 weeks), and the fourth group received both meloxicam and MnCl2 at the same doses and duration. Specimens of the olfactory bulbs were prepared for light and electron microscopy. An immunohistochemical study with a quantitative morphometry was performed using antibodies against glial fibrillary acidic protein (GFAP). The control group and meloxicam-treated group showed the same normal structure. MnCl2-treated group showed shrinkage of mitral nerve cells with dark peripheral nuclei as well as disorganization of mitral and granule nerve cells. The surrounding neuropil showed vacuolar spaces. Ultrastructurally, the mitral cells showed accumulation of lysosomes, swelling of mitochondria and irregularity of the nuclei. The nerve fibers contained swollen mitochondria with splitting and irregularity of the surrounding myelin sheaths. GFAP immunoreaction showed a highly significant increase compared to control group. On the other hand, the group that received both meloxicam and MnCl2 showed less marked histological changes. It was concluded that manganese induced structural changes in the olfactory bulb of albino rat that were ameliorated by concomitant use of meloxicam.

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Section: Discussionsupporting

confidence: 92%

“…These findings coincided with a previous study that showed alteration of the periodic pattern of myelin in Mn-treated mice [ 6 ]. Mitochondrial degeneration was also observed in the synapses of neurons in rat cerebral cortex after treatment with Mn [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of manganese on the olfactory bulb of adult male albino rat and the role of meloxicam: A histological and immunohistochemical study

Mousa

Shehab

2015

J Microsc Ultrastruct

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“…Notably, dopaminergic soma in the pars compacta are typically spared in manganism (Olanow 2004; Olanow et al 1996). A key feature of the reactive gliosis observed in human and experimental manganism is the presence of Alzheimer type II astrocytosis (Bikashvili et al 2001; Pentschew et al 1963). Ultrastructural studies report that reactive astrocytes and microglia surround degenerating neurons and contain increased numbers of large secondary lysosomes, indicative of an active phagocytic process (Bikashvili et al 2001).…”

Section: Neuropathological Characteristics Of Mn Exposurementioning

confidence: 99%

“…A key feature of the reactive gliosis observed in human and experimental manganism is the presence of Alzheimer type II astrocytosis (Bikashvili et al 2001; Pentschew et al 1963). Ultrastructural studies report that reactive astrocytes and microglia surround degenerating neurons and contain increased numbers of large secondary lysosomes, indicative of an active phagocytic process (Bikashvili et al 2001). Additionally, it has been reported that Mn induces astrogliosis in the pre-frontal cortex of exposed Cynomolgus macaques and that activated astrocytes in this model were noted proximal to degenerating neurons that expressed amyloid- β precursor-like protein 1 (Guilarte et al 2008b).…”

Section: Neuropathological Characteristics Of Mn Exposurementioning

confidence: 99%

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

et al. 2009

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The purpose of this review is to highlight recent advances in the neuropathology associated with Mn exposures. We commence with a discussion on occupational manganism and clinical aspects of the disorder. This is followed by novel considerations on Mn transport (see also chapter by Yokel, this volume), advancing new hypotheses on the involvement of several transporters in Mn entry into the brain. This is followed by a brief description of the effects of Mn on neurotransmitter systems that are putative modulators of dopamine (DA) biology (the primary target of Mn neurotoxicity), as well as its effects on mitochondrial dysfunction and disruption of cellular energy metabolism. Next, we discuss inflammatory activation of glia in neuronal injury and how disruption of synaptic transmission and glial-neuronal communication may serve as underlying mechanisms of Mn-induced neurodegeneration commensurate with the cross-talk between glia and neurons. We conclude with a discussion on therapeutic aspects of Mn exposure. Emphasis is directed at treatment modalities and the utility of chelators in attenuating the neurodegenerative sequelae of exposure to Mn. For additional reading on several topics inherent to this review as well as others, the reader may wish to consult Aschner and Dorman (Toxicological Review 25:147–154, 2007) and Bowman et al. (Metals and neurodegeneration, 2009).

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Sodium P-Aminosalicylic Acid Improved Manganese-Induced Learning and Memory Dysfunction via Restoring the Ultrastructural Alterations and γ-Aminobutyric Acid Metabolism Imbalance in the Basal Ganglia

Chen

Luo

et al. 2016

Biol Trace Elem Res

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Excessive intake of manganese (Mn) may cause neurotoxicity. Sodium para-aminosalicylic acid (PAS-Na) has been used successfully in the treatment of Mn-induced neurotoxicity. The γ-aminobutyric acid (GABA) is related with learning and memory abilities. However, the mechanism of PAS-Na on improving Mn-induced behavioral deficits is unclear. The current study was aimed to investigate the effects of PAS-Na on Mn-induced behavioral deficits and the involvement of ultrastructural alterations and γ-aminobutyric acid (GABA) metabolism in the basal ganglia of rats. Sprague-Dawley rats received daily intraperitoneally injections of 15 mg/kg MnCl.4HO, 5d/week for 4 weeks, followed by a daily back subcutaneously (sc.) dose of PAS-Na (100 and 200 mg/kg), 5 days/week for another 3 or 6 weeks. Mn exposure for 4 weeks and then ceased Mn exposure for 3 or 6 weeks impaired spatial learning and memory abilities, and these effects were long-lasting. Moreover, Mn exposure caused ultrastructural alterations in the basal ganglia expressed as swollen neuronal with increasing the electron density in the protrusions structure and fuzzed the interval of neuropil, together with swollen, focal hyperplasia, and hypertrophy of astrocytes. Additionally, the results also indicated that Mn exposure increased Glu/GABA values as by feedback loops controlling GAT-1, GABA mRNA and GABA protein expression through decreasing GABA transporter 1(GAT-1) and GABA A receptor (GABA) mRNA expression, and increasing GABA protein expression in the basal ganglia. But Mn exposure had no effects on GAT-1 protein expression. PAS-Na treatment for 3 or 6 weeks effectively restored the above-mentioned adverse effects induced by Mn. In conclusion, these findings suggest the involvement of GABA metabolism and ultrastructural alterations of basal ganglia in PAS-Na's protective effects on the spatial learning and memory abilities.

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Untitled

Cited by 6 publications

References 13 publications

The effect of manganese on the olfactory bulb of adult male albino rat and the role of meloxicam: A histological and immunohistochemical study

The effect of manganese on the olfactory bulb of adult male albino rat and the role of meloxicam: A histological and immunohistochemical study

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

Sodium P-Aminosalicylic Acid Improved Manganese-Induced Learning and Memory Dysfunction via Restoring the Ultrastructural Alterations and γ-Aminobutyric Acid Metabolism Imbalance in the Basal Ganglia

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