2003
DOI: 10.1023/a:1021644027850
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Abstract: Over the last 20 years the JAK/STAT signal transduction pathway has been extensively studied. An enormous amount of data on different cell signal transduction pathways is now available. The JAK/STAT signal transduction pathway is one of the intracellular signaling pathways activated by cytokines and growth factors that was first studied in the hematopoietic system, but recent data demonstrate that this signal transduction is also greatly utilized by other systems. The JAK/STAT pathway is a signaling cascade th… Show more

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Cited by 20 publications
(14 citation statements)
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“…JAK proteins are phosphorylated when cytokines bind to their specific receptors, subsequently activating STATs. STATs are a family of cytoplasmic proteins with Src homology-2 (SH2) domains that act as signal messengers and transcription factors [22]. Based on the findings presented, we examined whether doxazosin suppressed the phosphorylation of JAK and STATs in carcinoma cells.…”
Section: Resultsmentioning
confidence: 99%
“…JAK proteins are phosphorylated when cytokines bind to their specific receptors, subsequently activating STATs. STATs are a family of cytoplasmic proteins with Src homology-2 (SH2) domains that act as signal messengers and transcription factors [22]. Based on the findings presented, we examined whether doxazosin suppressed the phosphorylation of JAK and STATs in carcinoma cells.…”
Section: Resultsmentioning
confidence: 99%
“…The JAK-STAT pathway has an essential role in driving a variety of biological responses to cytokines [6]. The effect of TNF-α on the phosphorylation of STAT3 was examined.…”
Section: Resultsmentioning
confidence: 99%
“…The activation of the JAK-STAT pathway leads to a rapid signaling from the cell surface to the nucleus [6]. JAK proteins are phosphorylated when cytokines bind to specific receptors, and subsequently activate STATs.…”
Section: Introductionmentioning
confidence: 99%
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