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Dang, H.S.; Jaiswal, D. D.; Pullat, V.R.; Mishra, Umesh

doi:10.1023/a:1016015222878

Cited by 17 publications

(2 citation statements)

References 2 publications

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“…However, inhalation has been observed to be the predominant route (∼44% of total cases) of internal contamination with actinides, which has occurred in French CEA-AREWA centers during 1970–2003 . Notably, the long-term inhalation of Th-dust was found to cause pneumoconiosis and lung carcinogenesis in Chinese miners (average Th in lung, 0.4 mg). − Moreover, a significant level of Th has been reported in the blood (370–3000 ng/L), hair (19–2388 ng/g), and urine (18–906 ng/L) of Th-workers of several countries as compared to nonoccupationally exposed populations. − Indeed, the level of Th in hair of Iraq and Chinese women were found to be associated with the risk of congenital anomalies in their offspring. − Thus, these reports suggested significant adverse health effects of Th in humans after exposure to Th-containing dust. Lungs being the primary target organ of exposure, understanding the effect of Th on human lung alveolar epithelial cells is extremely important.…”

Section: Introductionmentioning

confidence: 99%

Thorium Alters Lung Surfactant Protein Expression in Alveolar Epithelial Cells: In Vitro and In Vivo Investigation

Das,

Ali,

Shetake

et al. 2024

Environ. Sci. Technol.

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Thorium-232 (Th), the most abundant naturally occurring nuclear fuel, has been identified as a sustainable source of energy. In view of its large-scale utilization and human evidence of lung disorders and carcinogenicity, it is imperative to understand the effect of Th exposure on lung cells. The present study investigated the effect of Th-dioxide (1–100 μg/mL, 24–48 h) on expression of surfactant proteins (SPs) (SP-A, SP-B, SP-C, and SP-D, which are essential to maintain lung’s surface tension and host-defense) in human lung cells (WI26 and A549), representative of alveolar cell type-I and type-II, respectively. Results demonstrated the inhibitory effect of Th on transcriptional expression of SP-A, SP-B, and SP-C. However, Th promoted the mRNA expression of SP-D in A549 and reduced its expression in WI26. To a significant extent, the effect of Th on SPs was found to be in accordance with their protein levels. Moreover, Th exposure altered the extracellular release of SP-D/A from A549, which remained unaltered in WI26. Our results suggested the differential role of oxidative stress and ATM and HSP90 signaling in Th-induced alterations of SPs. These effects of Th were found to be consistent in lung tissues of mice exposed to Th aerosols, suggesting a potential role of SPs in Th-associated lung disorders.

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Section: Introductionmentioning

confidence: 99%

Thorium Alters Lung Surfactant Protein Expression in Alveolar Epithelial Cells: In Vitro and In Vivo Investigation

Das,

Ali,

Shetake

et al. 2024

Environ. Sci. Technol.

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“…However, the growing use of Th as a fuel in the nuclear industry may envisage the increase of Th contamination into the environment through the mining, milling, purification, and reprocessing of fuels as well as the risk of accidental leakage from nuclear plant activities and waste storage sites. , The resultant higher risk of Th exposure for nuclear workers as well as for the general public is of global concern. A significant exposure of Th has been reported to workers in Th handling facilities of Brazil, China, India, Russia, Spain, U.K., and USA. − …”

Section: Introductionmentioning

confidence: 99%

Combined Thermodynamic, Theoretical, and Biological Study for Investigating N-(2-Acetamido)iminodiacetic Acid as a Potential Thorium Decorporation Agent

Sharma,

Ali,

Kumar

et al. 2023

Inorg. Chem.

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The most effective approach to mitigate the toxic effects of internal exposure of radiometals to humans is metal–ligand (ML) chelation therapy. Thorium (Th)-induced carcinogenesis as well as other health hazards to humans as a result of chronic internal exposure necessitates the development of efficient Th-decorporating agents. In this regard, chemical and biological studies were carried out to evaluate N-(2-Acetamido)iminodiacetic acid (ADA), a comparatively cost-effective, readily available, and biologically safe complexing agent for Th decorporation. In the present work, detailed thermodynamic studies for complexation of ADA with Th(IV) have been carried out to understand Th-ADA interaction, using potentiometry, calorimetry, electrospray ionization mass spectrometry, and theoretical studies, followed by its biological assessment for Th decorporation. Thermodynamic studies revealed the formation of strong Th-ADA complexes, which are enthalpically as well as entropically favored. Interestingly, density functional theory calculations, to obtain a thermodynamically favored mode of coordination, showed the uncommon trend of lower denticity of ADA in ML than in ML2, which has been explained on the basis of stabilization of ML by hydrogen bonding. The same was also reflected in the unusual trend of enthalpy for Th-ADA complexes. Biological experiments using human erythrocytes, whole human blood, and lung cells showed good cytocompatibility and ability of ADA to significantly prevent Th-induced hemolysis. Th removal of ADA from erythrocytes, human blood, and normal lung cells was found to be comparable with that of diethylenetriamine pentaacetate (DTPA), an FDA approved decorporating agent. The present study contributed significant data about Th complexation chemistry of ADA and its Th decorporation efficacy from human erythrocytes, blood, and lung cells.

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Activation Analysis

2003

Handbook of Nuclear Chemistry

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Cited by 17 publications

References 2 publications

Thorium Alters Lung Surfactant Protein Expression in Alveolar Epithelial Cells: In Vitro and In Vivo Investigation

Thorium Alters Lung Surfactant Protein Expression in Alveolar Epithelial Cells: In Vitro and In Vivo Investigation

Combined Thermodynamic, Theoretical, and Biological Study for Investigating N-(2-Acetamido)iminodiacetic Acid as a Potential Thorium Decorporation Agent

Activation Analysis

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