No. 99 Cerebral Blood Flow in Patients With Central Nervous Pathologies Associated With an Adequate Edentation Treatment

Stratulat, Ioan Sorin; Cuciureanu, Dan Iulian; Eva, L.; Dr, Roxana Maria Rad

doi:10.1016/j.pmrj.2014.08.231

Cited by 2 publications

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“…Cerebral blood flow is stable in general. However, studies have confirmed that mastication has positive effect on cerebral blood flow (Sesay et al, 2000;Luo et al, 2019), increasing blood flow in the motor area, somatosensory area, thalamus and cerebellum, and the number of pyramidal cells in the hippocampus (Momose et al, 1997;Stratulat et al, 2014). And it leads to changes in cerebral metabolism through glial cells.…”

Section: Discussionmentioning

confidence: 99%

Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment

Wang

Jiang

2022

Front. Neurosci.

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BackgroundThere is a dose-response relationship between tooth loss and cognitive impairment, while tooth loss can be an independent risk factor for Alzheimer's disease (AD) and vascular dementia (VaD). Tooth loss can also accelerate nerve damage and neurodegeneration. However, the associated mechanisms remain poorly understood.ObjectiveTo conduct a systematic review of animal experiments on cognitive decline caused by the loss of occlusal support performed over the past 10 years and summarize the possible underlying mechanisms.Methods“Tooth Loss,” “Edentulous,” “Tooth Extraction and Memory Loss,” “Cognition Impairment,” and “Dementia” were used as keywords to search PubMed, Embase, SCI, ScienceDirect, and OpenGrey. A total of 1,317 related articles from 2010 to 2021 were retrieved, 26 of which were included in the review after screening according to predetermined inclusion and exclusion criteria. Comprehensiveness was evaluated using ARRIVE guidelines and the risk of bias was assessed using SYCLE'S risk of bias tool.ResultsThe putative mechanisms underlying the cognitive impairment resulting from the loss of occlusal support are as follows: (1) The mechanical pathway, whereby tooth loss leads to masticatory motor system functional disorders. Masticatory organ activity and cerebral blood flow decrease. With reduced afferent stimulation of peripheral receptors (such as in the periodontal membrane) the strength of the connections between neural pathways is decreased, and the corresponding brain regions degenerate; (2) the aggravation pathway, in which tooth loss aggravates existing neurodegenerative changes. Tooth loss can accelerates nerve damage through apoptosis and mitochondrial autophagy, increases amyloid deposition in the brain; and (3) the long-term inflammatory stress pathway, which involves metabolic disorders, microbial-gut-brain axis, the activation of microglia and astrocytes, and inflammatory cascade effect in central nervous system.ConclusionThe loss of occlusal support may lead to cognitive dysfunction through the reduction of chewing-related stimuli, aggravation of nerve damage, and long-term inflammatory stress.

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Section: Discussionmentioning

confidence: 99%

Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment

Wang

Jiang

2022

Front. Neurosci.

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“…Some authors suppose that mastication changes the blood flow of the internal carotid artery, stimulating the oxygenation and perfusion of the brain. In addition, there is evidence that mastication increases the cortical blood flow of the somatosensory area, motor area, insular cortex, thalamus and cerebellum, and in pyramidal cells of the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

Mastication as a protective factor of the cognitive decline in adults: A qualitative systematic review

Chuhuaicura

Días

Arias

et al. 2019

International Dental Journal

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Introduction A relationship between masticatory function and cognition has been reported. It is proposed that mastication changes the blood flow stimulating the perfusion/oxygenation of the brain. This literature review analysed the relation between mastication as a protective factor of the cognitive decline and the changes produced at brain level in adults associated with the brain blood flow. Materials and methods A systematic review was performed according to the ‘Preferred Reporting Items for Systematic Reviews and Meta‐Analyses’ (PRISMA) criteria in PubMed/MEDLINE, Web of Science, Scopus and Embase. Primary studies were included with no limit on the publication date, conducted on humans, and that established a relation between mastication, brain blood flow and cognitive functions in adult patients. Results Nine clinical descriptive studies were selected and qualitatively analysed. The collected data suggest the greatest brain areas activated during mastication were the frontotemporal cortex, the caudate nucleus and the thalamus, revealing a positive correlation between chewing intensity and perfusion of the principal trigeminal nucleus. The increase in cerebral blood flow was measured by a local vasodilator effect resulting in increased neuronal metabolism in the region linked to learning and memory. In addition, partially edentulous participants had a marked prefrontal deactivation when they chewed without a prosthesis and presented a decrease in masticatory activity. Conclusion Masticatory function may act as a protective factor in those patients with cognition impairment and neurodegenerative diseases, suggesting some mechanisms among which is the increase of cerebral blood flow.

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No. 99 Cerebral Blood Flow in Patients With Central Nervous Pathologies Associated With an Adequate Edentation Treatment

Cited by 2 publications

References 0 publications

Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment

Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment

Mastication as a protective factor of the cognitive decline in adults: A qualitative systematic review

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