No additional effects of ursolic acid supplementation associated with combined exercise program on metabolic syndrome of postmenopausal women: A double-blind, randomized, placebo-controlled trial

Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

“…This characteristic may also explain inconsistent results in the abovementioned studies. Based on the above research, it is worth mentioning that oral administration of UA in humans was welltolerated, and adverse effects did not occur or were not statistically significant [94][95][96][97].…”

“…In the group receiving the intervention, 50% of them noted transient remission of metabolic syndrome (reduced body weight, body mass index, waist circumference and fasting glucose concentrations), whereas in the control group, no one achieved such remission [94]. On the other hand, a double-blind study of Cione et al on 26 postmenopausal women (61 ± 7 years) that lasted 8 weeks and was connected with an exercise intervention program presented no therapeutic effect of UA (450 mg/day) supplementation compared to the placebo group [95]. What is more, Lobo et al assessed the impact of UA on muscle strength and body mass gain in active men (18-35 years-old) on a high-protein diet for 8 weeks.…”

Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability

“…However, study showed no effects of UA on inflammatory markers. On the contrary, a randomized clinical trial done on postmenopausal women (n = 61) indicated that supplementation of UA (450 mg/day) combined with physical exercise had no effects on metabolic syndrome parameters [ 149 ]. Although metabolic syndrome parameters were not affected, an 8-week treatment with UA improved systolic blood pressure, insulin resistance, and HOMA-IR [ 149 ].…”

“…On the contrary, a randomized clinical trial done on postmenopausal women (n = 61) indicated that supplementation of UA (450 mg/day) combined with physical exercise had no effects on metabolic syndrome parameters [ 149 ]. Although metabolic syndrome parameters were not affected, an 8-week treatment with UA improved systolic blood pressure, insulin resistance, and HOMA-IR [ 149 ]. From these clinical trials, it is evident that UA has moderate anti-diabetic properties in humans, posing translational discrepancies from animal studies.…”