No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No‐go task: an fMRI study

ObjectivesSeveral genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder (BD) and schizophrenia (SZ) pathology. This polymorphism was recently found associated with increased amygdala activity in healthy controls and patients with BD. We performed a functional Magnetic Resonance Imaging (fMRI) study in a sample of BD and SZ cases and healthy controls to test for altered amygdala activity in carriers of the rs1006737 risk allele (AA/AG), and to investigate if there were differences across the diagnostic groups.MethodsRs1006737 was genotyped in 250 individuals (N = 66 BD, 61 SZ and 123 healthy controls), all of Northern European origin, who underwent an fMRI negative faces matching task. Statistical tests were performed with a model correcting for sex, age, diagnostic category and medication status in the total sample, and then in each diagnostic group.ResultsIn the total sample, carriers of the risk allele had increased activation in the left amygdala. Group-wise analyses showed that this effect was significant in the BD group, but not in the other diagnostic groups. However, there was no significant interaction effect for the risk allele between BD and the other groups.ConclusionsThese results indicate that CACNA1C SNP rs1006737 affects amygdala activity during emotional processing across all diagnostic groups. The current findings add to the growing body of knowledge of the pleiotropic effect of this polymorphism, and further support that ion channel dysregulation is involved in the underlying mechanisms of BD and SZ.

show abstract

“…Clinical assessment of the patients and healthy controls participating in the TOP study is described in details in a previous report [23].…”

Section: Methodsmentioning

confidence: 99%

CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…Few investigations in BD focus on ACC activation during motor inhibition; none directly compare adult and pediatric BD. Data comparing motor inhibition in children with mania vs. healthy comparisons found decreased ACC activity (13), while in a prior study adults with BD didn’t differ from healthy comparisons (27). In the present study, child BD had decreased ACC activation during failed motor inhibition compared to age-matched HV and adult BD, whereas adult BD had increased ACC activation relative to adult HV.…”

Section: Discussionmentioning

confidence: 84%

A Developmental Study of the Neural Circuitry Mediating Motor Inhibition in Bipolar Disorder

Weathers¹,

Stringaris

Deveney³

et al. 2012

AJP

View full text Add to dashboard Cite

Objective Despite increased interest in the developmental trajectory of the pathophysiology mediating bipolar disorder (BD), few studies compare adults and youths with BD. Deficits in motor inhibition are thought to play an important role in the pathophysiology of BD across the age spectrum. Here we compare neural circuitry mediating this process in youths vs. adults with BD and healthy volunteers. Method fMRI data from 89 subjects (16 BD youth, 23 BD adults, 21 healthy children, 29 healthy adults) were acquired while subjects performed the stop-signal task. Results During failed inhibition, an age group x diagnosis interaction manifested in the anterior cingulate cortex (ACC), with child BD participants showing hypoactivation relative to healthy children and adult BD, and adult BD showing hyperactivation relative to healthy adults. During successful inhibition, a main effect of diagnosis emerged in the right nucleus accumbens and left ventral prefrontal cortex, with bipolar individuals, irrespective of age, showing less activation than healthy participants. Conclusions Child BD and adult BD both show ACC dysfunction during failed motor inhibition, although the nature of that dysfunction differs between groups. Adults and youth with BD show similar deficits in nucleus accumbens and ventral prefrontal cortex activation during successful inhibition. Therefore, while subcortical and VPFC hypoactivation is present in BD across the lifespan, ACC dysfunction varies developmentally, with reduced ACC activation in child BD and increased activation in adult BD during failed inhibition. Longitudinal fMRI studies on the developmental trajectory of the neural circuitry mediating motor inhibition in BD are warranted.

show abstract

“…The average sample size per study was 14.3 ± 4.49 euthymic, 11.4 ± 3.29 manic, and 11.4 ± 2.30 depressed patients. There were 22 studies using emotional paradigms (29–50) and 28 studies using cognitive paradigms (4, 5, 10, 11, 51–74). In addition, we also included 26 studies using an ROI analysis in a separate set of meta‐analyses.…”

Section: Resultsmentioning

confidence: 99%

A quantitative meta-analysis of fMRI studies in bipolar disorder

et al. 2011

View full text Add to dashboard Cite

show abstract

No altered dorsal anterior cingulate activation in bipolar II disorder patients during a Go/No‐go task: an fMRI study

Abstract: These findings do not support the hypothesis of abnormal dACC activity during a Go/No-go task in BD II patients.

Cited by 24 publications

References 61 publications

CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls

CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls

A Developmental Study of the Neural Circuitry Mediating Motor Inhibition in Bipolar Disorder

A quantitative meta-analysis of fMRI studies in bipolar disorder

Contact Info

Product

Resources

About