No apparent correlation between Behçet’s disease and oxidative stress disturbance

Abstract

Behçet's disease (BD) is a chronic, progressive and inflammatory multisystemic disease, that significantly affects the cardiovascular system. Oxidative stress (OS) is a disturbance in oxidant/antioxidant balance in favor of oxidants. The OS that increases acutely and chronically due to the inflammatory process plays an important role in the pathogenesis of the cardiovascular system effects of the disease by causing endothelial dysfunction in vascular structures. The aim of our study was to investigate the relationship between OS and myocardial perfusion, which is based on microvascular dysfunction, in BD.Material and method: Twenty-seven patients with BD (16 M, 11 F, mean age: 38.7 ± 9.4 years) and 22 healthy volunteers (12 M, 10 F, mean age: 35.8 ± 6.5 years) participated in our study. Technetium-99m methoxyisobutylisonitrile single photon emission computed tomography (Tc-99m MIBI SPECT) stress-rest test was performed with two-day protocol. Myocardial perfusion scores (summed stress score, summed rest score, summed difference score, fix defect score) and perfusion defect prevalence (stress, rest, ischemic and fixed) were determined as the percentage of left ventricle. Coronary angiography was performed in patients with abnormal myocardial perfusion scintigraphy. For OS analysis, the blood samples were taken immediately before the first imaging procedure and were studied for malondialdehyde, glutathione, nitrite, nitrate, vitamin C, retinol, and carotene.Results: In the BD group, a total of 9 patients had abnormal findings in their stress and rest electrocardiography. Perfusion defect in myocardial perfusion scintigraphy was observed in 14 patients (51.8%). Twelve patients accepted coronary angiography, and their results were normal. In the comparison of myocardial perfusion scores, perfusion defect prevalence and OS parameters, there was a significant difference between the BD and control groups. In the BD group, no correlation was observed between myocardial perfusion scores, perfusion defect prevalence and OS parameters.Conclusion: Defects in myocardial perfusion and increase in OS were observed in BD; however, there was no correlation between the two findings in the inactive period. In other words, the prevalence and intensity of myocardial perfusion defects can vary at different OS levels.

Association between Red Cell Distribution Width and Disease Activity in Patients with Behcet’s Disease

“…So, they are prone to oxidative damage, which reduces cell survival and induces the release of juvenile erythrocytes into blood circulation. There are several studies available in the literature regarding this subject [32][33][34], in which oxidative response was found to be disrupted in both active and inactive BD patients.…”

The estrogen‑like protective effect of Lycium barbarum polysaccharides in reducing oxidative stress on myocardial cells from ovariectomized rats

“…Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and the ability of the body to readily detoxify reactive intermediates or to repair the resulting damage (12). Numerous studies have demonstrated that oxidative stress is an important factor underlying abnormal cardiovascular system structure (13)(14)(15). In addition, various cardiovascular diseases, including hypertension, atherosclerosis, myocardial ischemia, ischemia-reperfusion injury, myocardial hypertrophy and heart failure, are associated with an increase in ROS generation.…”