No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study

Stoica, Roxana Adriana; Guja, Cristian; Stoian, Anca Pantea; Staden, Raluca Ioana Stefan-van; Popa-Tudor, Ioana; Stefan, Simona; Ancuceanu, Robert; Serafinceanu, Cristian; Tirgoviste, Constantin Ionescu

doi:10.3390/medicina57010025

Cited by 3 publications

(2 citation statements)

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“…The data regarding insulin sensitivity and resistance in the course of thyroid dysfunctions remain controversial (11,22,(26)(27)(28). In a previous cross-sectional study in the Romanian population, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) predicted a thyroid-stimulating hormone (TSH) increase in obese patients with newly diagnosed thyroid pathology (29).…”

Section: Discussionmentioning

confidence: 99%

“…Assuming that the probability of the exposure variable (hypothyroidism) in women from the general population is ~8% (21), with a 1:1 ratio for cases and controls, a prevalence of 25% of IR (22), and 80% power, a minimum (total) sample size of 150 was necessary for a univariate logistic regression model using a score test and a minimum (total) sample size of 187 for the same model using a Wald test, to be able to detect an odds ratio of 4 (log OR, 1.39). For the multivariate analysis, the sample size needed was much larger, but the pilot study data allowed for the assessment of such a study and more precise calculations for such a study.…”

Section: Case Studymentioning

confidence: 99%

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Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study

et al. 2021

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Longitudinal studies have indicated an association between thyroid function and insulin resistance (IR) or a neutral relationship. Both the lowest tertile of free thyroxine (fT4) and the highest tertile of free triiodothyronine (fT3) were found to be associated with IR in cross-sectional studies. The aim of the present study was to analyze the association between IR and subclinical hypothyroidism in a female adult population from Bucharest, Romania. This is a retrospective pilot case-control study that included female patients examined by two endocrinologists and a diabetologist in an outpatient clinic. The retrospective follow-up had a one-year duration and included the evaluation of thyroid function tests and IR indices based on fasting insulinemia and C-peptide. The study included 176 women, 91 with subclinical hypothyroidism, with a median age of 60±17 years and a mean body mass index (BMI) of 27.79±4.76 kg/m 2 . The majority of the population (50%) was diagnosed with autoimmune thyroiditis, and 17.05% with goitre. The univariate logistic regression using hypothyroidism as the explaining variable found no evidence of a significant relationship between a decreased thyroid function and IR (OR 1.32; P=0.36). Metabolic syndrome was probably the most important determinant of IR in the population group studied. Thus, it was not the thyroid function per se, but the coexistence of other elements of this syndrome that prevailed in determining IR. Advantages to the study are the design that permitted evaluation of IR and the thyroid function at different moments in time as well as the uniformity of the blood tests. The multivariate analyses were adjusted for age, lipid profile and treatment; however, one limiting factor was the absence of other hormonal blood tests. In summary, there was no association between the thyroid function tests (TSH, fT4) and IR indices in adult Romanian women in a case-control study with one-year retrospective follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Case Studymentioning

confidence: 99%

Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study

et al. 2021

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Effects of vitamin D supplementation on metabolic syndrome parameters in patients with obesity or diabetes in Brazil, Europe, and the United States: A systematic review and meta-analysis

Oliveira,

Macedo-Silva,

Coutinho-Cruz

et al. 2024

The Journal of Steroid Biochemistry and Molecular Biology

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Vitamin D and the Thyroid: A Critical Review of the Current Evidence

Leko

Jureško

Rozić

et al. 2023

IJMS

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Vitamin D is necessary for the normal functioning of many organs, including the thyroid gland. It is, therefore, not surprising that vitamin D deficiency is considered a risk factor for the development of many thyroid disorders, including autoimmune thyroid diseases and thyroid cancer. However, the interaction between vitamin D and thyroid function is still not fully understood. This review discusses studies involving human subjects that (1) compared vitamin D status (primarily determined by serum calcidiol (25-hydroxyvitamin D [25(OH)D]) levels) with thyroid function assessed by thyroid stimulating hormone (TSH), thyroid hormones, and anti-thyroid antibody levels; and (2) evaluated the effect of vitamin D supplementation on thyroid function. Due to the many inconsistencies in the results between the studies, it is still difficult to draw a definite conclusion on how vitamin D status affects thyroid function. Studies in healthy participants observed either a negative correlation or no association between TSH and 25(OH)D levels, while the results for thyroid hormones showed high variability. Many studies have observed a negative association between anti-thyroid antibodies and 25(OH)D levels, but equally many studies have failed to observe such an association. Regarding the studies that examined the effect of vitamin D supplementation on thyroid function, almost all observed a decrease in anti-thyroid antibody levels after vitamin D supplementation. Factors that could contribute to the high variability between the studies are the use of different assays for the measurement of serum 25(OH)D levels and the confounding effects of sex, age, body-mass index, dietary habits, smoking, and the time of year when the samples were collected. In conclusion, additional studies with larger numbers of participants are needed to fully understand the effect of vitamin D on thyroid function.

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No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study

Cited by 3 publications

References 47 publications

Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study

Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study

Effects of vitamin D supplementation on metabolic syndrome parameters in patients with obesity or diabetes in Brazil, Europe, and the United States: A systematic review and meta-analysis

Vitamin D and the Thyroid: A Critical Review of the Current Evidence

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