No association between BRCA mutations and sex ratio in offspring of Pakistani BRCA mutation carriers

Rashid, Muhammad Usman; Torres, Diana; Zaidi, Alia; Rasheed, Farah; Sultan, Faisal; Shakoori, Abdul Rauf; Amin, Asim; Hamann, Ute

doi:10.1007/s10549-007-9521-z

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…[30] However, sex ratio of offspring of BRCA1/2 carriers was not different from the non-carriers in the Pakistani population. [31] Males identified with BRCA1/2 mutations have an increased risk of multiple cancers. [22] Similarly,…”

Section: High-penetrance Genes Brca1 and Brca2mentioning

confidence: 99%

Inherited Genetic Susceptibility to Breast Cancer in Pakistan

Muhammad

Nawaz

Khan

et al. 2018

J Cancer Allied Spec

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Breast cancer is a heterogeneous disease. Several genetic, environmental and lifestyle factors are involved in the aetiology of this disease. Genetic risk factors include alterations (mutations) in genes conferring risks to develop breast cancer. Depending on the associated lifetime risks of this malignancy, these genes are categorised into high-, moderate- and low-risk genes. Women carrying mutations in these genes are at an increased risk to develop breast cancer, ovarian cancer and several other malignancies. Breast carcinoma is the most reported malignancy in Pakistani females. Pakistan is a developing country with most of its population living in rural areas; hence, optimal healthcare facilities are inadequate for the early diagnosis and prevention of this disease. Hence, identification of individuals carrying mutations is clinically relevant as different strategies are available for the early detection, risk reduction and better management of this malignancy. This review summarises the findings of the major studies conducted in Pakistan to investigate the contribution of breast cancer predisposing genes. Furthermore, implications of the current studies and future research potentials are discussed.Key words: Breast cancer gene 1/2, breast cancer, checkpoint kinase 2, genetic susceptibility, Pakistan, RAD51C, tumour Protein p53, Vitamin D receptor

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Section: High-penetrance Genes Brca1 and Brca2mentioning

confidence: 99%

Inherited Genetic Susceptibility to Breast Cancer in Pakistan

Muhammad

Nawaz

Khan

et al. 2018

J Cancer Allied Spec

View full text Add to dashboard Cite

show abstract

“…There is evidence that altered BRCA1/2 may result in a skewed sex ratio at birth (SRB, male proportion) against male birth [10,11]. However, results of other studies did not show significant deviation from the expected value [12,13]. BRCA1 contains a C-terminal domain (named BRCT).…”

Section: To the Editormentioning

confidence: 99%

Association between polymorphisms of XRCC1 and offspring sex ratio at births in families of female breast cancer patients

Saadat

2009

Breast Cancer Res Treat

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No association between BRCA mutations and sex ratio in offspring of Pakistani BRCA mutation carriers

Cited by 2 publications

References 15 publications

Inherited Genetic Susceptibility to Breast Cancer in Pakistan

Inherited Genetic Susceptibility to Breast Cancer in Pakistan

Association between polymorphisms of XRCC1 and offspring sex ratio at births in families of female breast cancer patients

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