No association between HPV vaccination and infertility in U.S. females 18–33 years old

Abstract

Background-Human papillomavirus (HPV) vaccines have been recommended as primary prevention of HPV-related cancers for over 10 years in the United States, and evidence reveals decreased incidence of HPV infections following vaccination. However, concerns have been raised that HPV vaccines could decrease fertility. This study examined the relationship between HPV immunization and self-reported infertility in a nationally representative sample. Methods-Data from the 2013-2016 National Health and Nutrition Examination Survey were analyzed to asses likelihood of self-reported infertility among women aged 20 to 33, who were young enough to have been offered HPV vaccines and old enough to have been queried about infertility (n=1,114). Two logistic regression models, stratified by marital history, examined potential associations between HPV vaccination and infertility. Model 1 assessed the likelihood of infertility among women who had never been pregnant or whose pregnancies occurred prior to HPV vaccination. Model 2 accounted for the possibility of latent and/or non-permanent postvaccine infertility by including all women 20-33 years old who reported any 12-month period of infertility.

Investigating trends in those who experience menstrual bleeding changes after SARS-CoV-2 vaccination

“…Despite this, menstruation is seldom considered a variable during vaccine trials aside from determining last menstrual period as part of established protections against volunteers being or getting pregnant. The vast majority of research that has been conducted regarding reproductive and menstrual function centers around whether or not live and attenuated vaccines are safe to give someone who is pregnant (61)(62)(63)(64), or if it affects fertility (65,66). The research that has been conducted on menstrual cycles specifically is often not able to establish a causal link, as the data is obtained through retrospective surveys or data mining (67,68) and randomized controlled trials often do not allow a mechanism for reporting these changes (44).…”

Association Between Human Papillomavirus Vaccination and Primary Ovarian Insufficiency in a Nationwide Cohort

“…Additionally, a recent cross-sectional study of survey data evaluated HPV vaccination and the rate of self-reported infertility and found no association. 20 Although this is a reassuring result, the highly heterogeneous nature of infertility and the cross-sectional design preclude this study from adding significantly to the evidence on HPV vaccination and the rate of primary ovarian insufficiency.…”

Tendência Da Imunização Contra O HPV Na População Masculina No Estado Do Tocantins Entre Os Anos De 2017-2019

“…Este divulga informações pseudocientíficas que comprometem à segurança das vacinas 21 . Concepções que após a administração da 4vHPV pode causar efeitos colaterais como infertilidade e até mesmo levar a morte não possui veracidade científica 22,23 . Eventos como tontura, desmaio e dores locais são efeitos psicogênicos que ocorrem quando um indivíduo é vacinado em conjunto presenciando reações de outros no recebendo da vacina.…”