No association between iron status and self‐reported health‐related quality of life in 16,375 Danish blood donors: results from the Danish Blood Donor Study

Rigas, Andreas S.; Pedersen, Ole Birger; Sørensen, Cecilie J.; Sørensen, Erik; Kotzé, Sebastian; Petersen, Mikkel Steen; Thørner, Lise Wegner; Hjalgrim, Henrik; Erikstrup, Christian; Ullum, Henrik

doi:10.1111/trf.13085

Cited by 35 publications

(30 citation statements)

References 17 publications

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“…However, one short‐term study in female blood donors provided with daily iron or a placebo found no clinically significant effect on fatigue, depression, exercise performance or quality of life (QoL) scores when tested at 4 weeks after donating (Waldvogel et al , ). In a larger cross‐sectional study of more than 16 000 blood donors, lower iron status was not accompanied by lower physical or mental QoL scores (Rigas et al , ). And, the even larger prospective INTERVAL study that randomized donors in the UK to standard (12 weeks in men, 16 weeks in women) or more frequent intervals found no significant differences in QoL, physical, or cognitive changes across groups, however, they did note more physical donation symptoms (e. g., tiredness, short of breath, restless legs), and lower Hb and ferritin values in the donors who donated in the more frequent groups (DiAngelantonio et al , ) It is important to note that QoL and fatigue scores are subject to accommodation, meaning that donors may adjust their activity levels as they become progressively iron depleted and may not notice the accommodation until after iron supplementation, which was not part of either study.…”

Section: Adverse Effects Of Iron Depletionmentioning

confidence: 97%

How do we manage iron deficiency after blood donation?

Kiss

Vassallo

2018

Br J Haematol

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Blood donors and the RBCs and other components they willingly provide are essential in the delivery of healthcare in all parts of the world. Nearly 70% of donated blood comes from repeat or committed donors. The amount of iron removed in the 10 min or so it takes to withdraw a unit of blood (500 ml, plus 25 ml for testing) requires over 24 weeks to replace on a "standard" diet, i.e., without added iron in the form of supplements The cumulative effect of repeat blood donations without adequate iron replacement or a longer wait between donations results in iron deficiency (ID) in many donors, low haemoglobin deferral (~8% of donation attempts), and frank anaemia in some. Moreover, ID can be associated with side effects that can impact a blood donor's health, such as fatigue, cognitive changes and other neuromuscular symptoms. In an effort to better identify and prevent ID, blood collection agencies are recommending various strategies, including changes in the donation interval, donation frequency, testing of iron status and iron supplementation. In this review, we present the evidence basis for these strategies and suggest our own approaches to improving iron balance in blood donors.

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Section: Adverse Effects Of Iron Depletionmentioning

confidence: 97%

How do we manage iron deficiency after blood donation?

Kiss

Vassallo

2018

Br J Haematol

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“…8 Adverse health effects have been linked to iron deficiency and anemia, though the significance of iron deficiency without anemia in otherwise healthy individuals is still unclear. 1,12 Safe donation intervals were established in the 1940s using hemoglobin recovery as a marker for donor recovery. 13,14 These studies have only limited applicability today owing to factors such as study settings and changes in donor demographics.…”

Section: Introductionmentioning

confidence: 99%

Retrospective analysis of capillary hemoglobin recovery in nearly 1 200 000 blood donor returns

et al. 2017

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Key Points• We used a registry containing all 1 163 524 blood donor returns that took place in Finland between 2010 and 2015 to evaluate cHb recovery.• Average recovery times for cHb to return to the level of the preceding donation were longer than the minimum allowed donation intervals.Measuring the concentration of capillary hemoglobin (cHb) is a standard procedure before blood donation. To further assess the time period needed for cHb recovery after blood donation and to have a more in-depth understanding of features of recovery, we used datamining tools in a large, retrospective data pool containing all 1 163 524 donor returns that took place in Finland in 2010 to 2015. The results show that the average recovery times for cHb to return back to the level preceding donation were substantially longer, over 200 days in all age groups, than were the minimum allowed donation intervals. cHb recovery was especially poor in women under the age of 30 who returned to donate soon after the minimum allowed donation interval. It was of interest that frequent donors recovered substantially faster, with the average recovery times of ;100 days in men and ;200 days in women, than did infrequent donors, suggesting that there is a subpopulation of donors who can donate frequently without fear of iron deficiency. Return interval in fact explained only 1% of the variation in cHb recovery, which points to unknown, individual features, such as genetic or lifestyle factors, warranting further studies and suggesting that simply extending the allowed donation intervals may not suffice to improve cHb recovery. The study demonstrates that data mining of blood bank records is a powerful tool for depicting features of blood donor population.

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“…Analysis of responses to health survey questionnaires given to more than 25,000 participating donors did not show any effect on quality of life or cognitive function despite increases in the frequency of donation above standard practice. In another study conducted at an appropriate scale on more than 16,000 Danish donors, there was no evidence for an association between reduced iron stores, as measured by serum ferritin, and self‐reported health‐related quality of life . Another suitably scaled study from Rigas and colleagues appears in this edition.…”

mentioning

confidence: 96%

“…In another study conducted at an appropriate scale on more than 16,000 Danish donors, there was no evidence for an association between reduced iron stores, as measured by serum ferritin, and self-reported health-related quality of life. 13 Another suitably scaled study from Rigas and colleagues 14 appears in this edition. Using national data, they report that scholastic achievement was not influenced by the frequency of donation before pregnancy.…”

mentioning

confidence: 99%