No Association Between Left-Breast Radiation Therapy or Breast Arterial Calcification and Long-Term Cardiac Events in Patients with Breast Cancer

Soran, Özlem; Vargo, John A.; Polat, Ahmet Veysel; Soran, Atilla; Sumkin, Jules H.; Beriwal, Sushil

doi:10.1089/jwh.2014.4748

Cited by 11 publications

(5 citation statements)

References 17 publications

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“…Coblentz C et al first observed that radiotherapy promoted TAC in a patient who received radiotherapy for Hodgkin lymphoma in childhood (Coblentz et al, 1986), then other researchers observed that radiotherapy promoted coronary artery and aorta calcification in Hodgkin lymphoma patients with chest radiotherapy (Apter et al, 2006;Miki et al, 2020). However, this study found no correlation between radiotherapy and progression of TAC in breast cancer survivors which is consistent with previous studies (Chang et al, 2013;Soran et al, 2014;Takx et al, 2017). There are some reasons for the different results: Hodgkin lymphoma patients were treated with mediastinal radiotherapy, so the aorta was in the radiotherapy area and received more radiation exposure dose.…”

Section: Discussionsupporting

confidence: 88%

Dexamethasone is Associated With a Lower Risk of the Progression of Thoracic Aortic Calcification in Breast Cancer Survivors

Liu

et al. 2021

Front. Pharmacol.

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Background and Purpose: Breast cancer survivors have an increased cardiovascular risk, and vascular calcification is the pathological basis of cardiovascular disease. Some factors that affect the progression of thoracic aortic calcification (TAC) in survivors are unclear, and this study aims to explore the relationship between dexamethasone or radiotherapy and the progression of TAC in survivors.Materials and Methods: This study included 189 female patients with breast cancer, and they were divided into the progression and non-progression TAC groups. Radiation or dexamethasone doses, and related laboratory parameters were collected.Results: The cumulative dose of dexamethasone was higher [40 (10–180) mg versus 180 (80–270) mg, p < 0.001], and the cycle was longer [4 (1–6) cycles versus 6 (4–8) cycles, p < 0.001] in the non-progression TAC group. The cumulative dose (r = −0.303, p < 0.001) and cycle (r = −0.357, p < 0.001) of dexamethasone were negatively correlated with the level of increased TAC Agatston scores in survivors. Logistic regression analysis showed that dexamethasone was a protective factor for the progression of TAC (p = 0.029, odds ratio = 0.263, 95% confidence interval = 0.08–0.872). However, there wasn’t significant relationship between radiotherapy, radiation dose, follow-up time and the progression of TAC (all p > 0.05). In addition, aorta volume was positively correlated with the level of increased TAC Agatston scores in intensity modulated radiation therapy (r = 0.460, p < 0.001).Conclusion: Dexamethasone is associated with a lower risk of the progression of TAC in breast cancer survivors, and there’s no correlation between radiotherapy and progression of TAC, but the aorta volume may be a predictor of the severity of progression of TAC.

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Section: Discussionsupporting

confidence: 88%

Dexamethasone is Associated With a Lower Risk of the Progression of Thoracic Aortic Calcification in Breast Cancer Survivors

Liu

et al. 2021

Front. Pharmacol.

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“…They reported no statistically significant relationship between BAC observed on baseline mammography and BAC found on follow-up (post-RT) mammography and later cardiac events. They found that subdividing individuals with a left-sided tumor based on BAC did not predict cardiac events either [15]. We attribute the existence of different results to the diversity of study populations and the complexity of the relationship between the diseases that we think may affect cardiovascular events, let alone the fact that radiotherapy in a patient with breast cancer causes an intense pathophysiological change.…”

mentioning

confidence: 75%

“…There is only one research [15] studied the impact of RT on BAC that we could find in the English liter-…”

Section: Discussionmentioning

confidence: 99%

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Relationship of breast arterial calcification and radiotherapy

Karataş,

Kula,

Tunçbilek

2024

The European Research Journal

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Objective: The purpose of this research is to compare the pre and post-radiotherapy mammograms of patients who had breast-conserving surgery (BCS) and radiotherapy to see how radiotherapy affects breast arterial calcifications (BAC). Methods: The study retrospectively compared the mammography examinations at least 24 months after radiotherapy and pre-radiotherapy mammography examinations of 123 female patients diagnosed with breast cancer and treated with BCS and radiotherapy between December 2001 and July 2011. Results: Breast arterial calcifications (BAC) increased statistically significantly in 25 patients who underwent radiotherapy after BCS. Conclusion: Our results indicate that BAC increases significantly after RT, especially in breasts treated with radiotherapy, with age being also a risk factor for BAC development.

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“…Of the 76 studies, 35 investigated the risk of CVM with respect to RT laterality, 28 studies investigated the risk of CVEs with respect to RT laterality, 7,[10][11][12]16,18,20,22,24,33,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] 26 studies investigated the risk of CVM with respect to RT compared with no RT, 5,7,10,14,21,27,29,30,32,38,54,[58][59][60][61][62][63][64][65][66][67][68][69]…”

Section: Resultsmentioning

confidence: 99%

Cardiovascular Events and Mortality in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer: a Systematic Review

Taylor

Chan

Wan

et al. 2021

Hong Kong Journal of Radiology

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Objective : We performed a systematic review to quantify the cardiovascular risk of adjuvant radiotherapy (RT) for breast cancer. Methods: A literature search was conducted using MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to July 2020. Results: The literature search produced 7363 reports, of which 76 met our inclusion criteria. In studies comparing left-sided RT with right-sided RT, 7 of 35 (20%) studies found increased cardiovascular mortality, and 8 of 28 (29%) studies found increased cardiovascular events. In studies comparing patients who received RT with those who did not, 7 of 26 (27%) studies found increased cardiovascular mortality, and 5 of 22 (23%) studies found increased cardiovascular events. Conclusion:Most of the studies that found significant associations between laterality and cardiovascular risks included treatment periods that started prior to 1985, suggesting that modern RT techniques have minimised the cardiac exposure in breast cancer patients receiving RT. However, more focused studies must be conducted to investigate the long-term cardiovascular risk associated with modern RT techniques.

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No Association Between Left-Breast Radiation Therapy or Breast Arterial Calcification and Long-Term Cardiac Events in Patients with Breast Cancer

Abstract: In a large single-institutional observational study, no association was found between left-sided breast RT or BAC and subsequent cardiac events.

Cited by 11 publications

References 17 publications

Dexamethasone is Associated With a Lower Risk of the Progression of Thoracic Aortic Calcification in Breast Cancer Survivors

Dexamethasone is Associated With a Lower Risk of the Progression of Thoracic Aortic Calcification in Breast Cancer Survivors

Relationship of breast arterial calcification and radiotherapy

Cardiovascular Events and Mortality in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer: a Systematic Review

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