No association between marker D10S1423 and Alzheimer's disease

Bertram, Lars; Saunders, Aleister J.; Mullin, Kristina; Sampson, Andrew; Moscarillo, T J; Basset, S S; Go, Rodney C.P.; Blacker, Deborah; Tanzi, Rudolph E.

doi:10.1038/sj.mp.4001355

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…A second genome wide scan in a case‐control study also implicated the 10p13 region, and reported a significant association with the D10S1664 marker, which is 3 cM proximal to D10S1423 (Hiltunen et al 2001). Subsequently, three independent case‐control studies evaluated the role of the D10S1423 marker with AD (Majores et al 2000; Nishimura et al 2001; Bertram et al 2003), but only one confirmed the original finding (Majores et al 2000).…”

Section: Chromosome 10mentioning

confidence: 99%

Molecular Genetics of Late‐Onset Alzheimer's Disease

Kamboh

2004

Annals of Human Genetics

152

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SummaryLate-onset Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. Apolipoprotein E (APOE), especially the APOE * 4 allele, has been established as a strong susceptibility marker that accounts for nearly 30% of the risk in late-onset AD. However, as the APOE * 4 allele is neither necessary nor sufficient for the development of AD, it emphasizes the involvement of other genetic and/or environmental factors which, alone or in conjunction with APOE * 4, can modify the risk of AD. Recently, genome-wide linkage or linkage disequilibrium studies on late-onset AD have provided informative data for the existence of multiple putative genes for AD on several chromosomes, with the strongest evidence on chromosomes 12, 10, 9 and 6. This paper attempts to review the current progress on the identification of additional genetic loci for late-onset AD.

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