No association between plasma adiponectin levels and central auditory function in adults

Hwang, Juen-Haur; Tseng, Fen‐Yu; Liu, Tien‐Chen; Yang, Wei‐Shiung

doi:10.1007/s11011-014-9597-1

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…For example, genetic background, noise exposure, obstructive sleep apnea, metabolic syndrome, ototoxic agents, etc. [2][3][4][5][6][7][8][9][10][11][12][13][14]. Hypoxia, neural in ammation, oxidative stress damages, and caspase-dependent cell apoptosis in the auditory system were the most known mechanisms for ARHI [8,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Spirulina Prevent Caspase-Independent Apoptosis in the Cochlea and Brainstem of Senescence-Accelerated Prone-8 Mice

Chan

Lin

Hwang

2020

Preprint

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Background: Spirulina platensis water extract (SP) could decrease hearing degeneration via reducing oxidative stress damages in the auditory system of senescence-accelerated prone-8 (SAMP8) mice. This study aimed to investigate the effects of SP on the caspase-independent apoptosis in the cochlea and brainstem of SAMP8 mice.Methods: Twelve 11-month-old SAMP8 mice were randomly divided into two groups: control group (SAMP8 mice was fed a normal diet) and spirulina group (SAMP8 mice was fed a normal diet with oral supplementation SP for 6 weeks. Auditory brainstem responses (ABRs) were measured in the beginning and at the end of the study. Cochlear histology and immunochemistry and Western blotting of brainstem were performed at the end of the study.Results: Compared with control group, spirulina group had significantly lower ABR thresholds using click sound stimulation at the end of this study. The spirulina group had significantly higher counts of outer hair cells (OHC) and spiral ganglion neuron (SGN) density in the middle turn of the cochlea. The spirulina group had significantly lower expressions of poly (ADP-ribose) polymerase-1 (PARP-1) and apoptosis-inducing factor (AIF) in the cochlea. Also, the spirulina group had significantly lower expression of PARP-1, but not the AIF, in the brainstem.Conclusions: SP could decrease hearing degeneration in SAMP8 mice possibly via reducing caspase-independent apoptosis signal pathway in the cochlea and brainstem.

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Section: Introductionmentioning

confidence: 99%

Spirulina Prevent Caspase-Independent Apoptosis in the Cochlea and Brainstem of Senescence-Accelerated Prone-8 Mice

Chan

Lin

Hwang

2020

Preprint

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The association of obesity with hearing thresholds in women aged 18–40 years

et al. 2015

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An elevation in hearing thresholds and decrease in hearing sensitivity in adults, particularly due to aging, are quite common. Recent studies have shown that, apart from aging, various other factors also play a role in auditory changes. Studies on the association of hearing loss (HL) with obesity are limited in advanced age cases and present contradictions. In this study, the association between obesity and hearing thresholds in women aged 18-40 years has been assessed. Forty women diagnosed with obesity (mean age, 31.8 years) and 40 healthy non-obese female controls (mean age, 30.5 years) were included in this prospective study. Each subject was tested with low (250, 500, 1000 and 2000 Hz) and high (4000, 6000 and 8000 Hz) frequency audiometry. In the case and control groups, the average hearing thresholds at low frequencies were 16.03 ± 4.72 and 16.15 ± 2.72 (p = 0.885) for the right ear, respectively, and 16.15 ± 5.92 and 14.71 ± 3.18 (p = 0.180) for the left ear, respectively. The average hearing threshold levels at high frequencies were 20.70 ± 10.23 and 15.33 ± 3.87 (p = 0.003), respectively, for the right ear, and 22.91 ± 15.54 and 15.87 ± 4.35 (p = 0.007), respectively, for the left ear with statistical significance. This is the first report on the association of obesity with hearing threshold in women aged 18-40 years. We have demonstrated that obesity may affect hearing function, particularly that related to high frequencies. Hearing loss can be prevented by avoidance or control of obesity and its risk factors. Moreover, an auditory screening of obese cases at an early stage may provide early diagnosis of HL and may also contribute to their awareness in the fight against obesity.

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Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice

Chan

Hwang

2017

PLoS ONE

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To our knowledge, the effects of Spirulina platensis water extract (SP) on hearing function have not yet been reported. This study investigated the effects of SP on the function and redox status of the auditory system. Auditory brainstem responses and redox status were compared between two groups of 3-month-old senescence-accelerated prone-8 (SAMP8) mice: the control group was fed a normal diet, and the experimental group was fed a normal diet with oral supplementation of SP for 6 weeks. Compared with the control group, the experimental group had significantly lower hearing thresholds according to auditory brainstem responses measured using click sounds and 8-kHz tone burst sound stimulation at the end of this study. The experimental group had a shorter I-III interval of auditory brainstem responses with 16-kHz tone burst stimulation than the control group that was of borderline significance. Additionally, the experimental group had significantly higher mRNA expression of the superoxide dismutase and catalase genes in the cochlea and brainstem and significantly higher mRNA expression of the glutathione peroxidase gene in the cochlea. Further, the experimental group had significantly lower malondialdehyde levels in the cochlea and brainstem than the control group. However, tumor necrosis factor–α mRNA expression was not significantly different between the control and experimental groups. SP could decrease hearing degeneration in senescence-accelerated prone-8 mice possibly by increasing superoxide dismutase, catalase, and glutathione peroxidase gene expression and decreasing damage from oxidative stress in the cochlea and brainstem.

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No association between plasma adiponectin levels and central auditory function in adults

Cited by 3 publications

References 35 publications

Spirulina Prevent Caspase-Independent Apoptosis in the Cochlea and Brainstem of Senescence-Accelerated Prone-8 Mice

Spirulina Prevent Caspase-Independent Apoptosis in the Cochlea and Brainstem of Senescence-Accelerated Prone-8 Mice

The association of obesity with hearing thresholds in women aged 18–40 years

Effects of Spirulina on the functions and redox status of auditory system in senescence-accelerated prone-8 mice

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