No association between polymorphisms in the BDNF gene and age at onset in Huntington disease

Mai, Maren; Akkad, Amer D; Wieczorek, Stefan; Saft, Carsten; Andrich, Jürgen; Kraus, P. H.; Epplen, Jörg T.; Arning, Larissa

doi:10.1186/1471-2350-7-79

Cited by 15 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The distribution of BDNF genotypes in WD patients was similar to those described previously: 66 % for BDNF Val/Val in the current study, as compared to 65.4 % in Alzheimer’s disease (Ventriglia et al 2002), 64 % in Huntington’s disease (Mai et al 2006), 62.9 % in cervical dystonia (Groen et al 2012), and 60 % in multiple sclerosis (Mirowska-Guzel et al 2008). In the case of the BDNF C-270T polymorphism, the C/C genotype was noted in 88.2 % of Alzheimer’s disease patients (Kunugi et al 2001) and 68 % of multiple sclerosis patients (Mirowska-Guzel et al 2008), versus 86 % of WD patients in the current study.…”

Section: Discussionsupporting

confidence: 91%

Influence of BDNF polymorphisms on Wilson’s disease susceptibility and clinical course

et al. 2013

View full text Add to dashboard Cite

Susceptibility to Wilson’s disease (WD) and its clinical manifestations are thought to be affected by genetic factors, including polymorphisms. The role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases is now widely discussed. The aim of the present study was to evaluate the frequency of the BDNF Val66Met (G-196A) and C-270T polymorphisms in WD patients and in healthy controls, and to determine the role of these polymorphisms in the clinical characteristics of WD. We found that the BDNF Val/Val (−196 G/G) and −270 C/T genotypes occurred more frequently in WD patients than in healthy controls (66 % versus 45.5 %, p = 0.0001, and 14 % versus 6 %, p = 0.018, respectively). Similarly, symptomatic patients carried the BDNF Val/Val genotype more often than presymptomatic patients (75 % versus 53 %, p = 0.0097). No association was detected between any of the determined polymorphisms and the dominant form of the disease or the age of onset for WD.

show abstract

Section: Discussionsupporting

confidence: 91%

Influence of BDNF polymorphisms on Wilson’s disease susceptibility and clinical course

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Importantly, forebrain-specific BDNF-knock-out mice (Emx-BDNF KO mice) show a similar phenotype to that observed in the mouse models of HD [172,173] . In contrast to evidence suggesting involvement of BDNF in the pathophysiology of HD, no association between the Val-66Met polymorphism of the BDNF gene and onset/progression of HD has been reported [174][175][176][177][178] .…”

Section: Huntington Diseasementioning

confidence: 73%

New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases

Adachi

Numakawa

Richards

et al. 2014

WJBC

152

100

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) attracts increasing attention from both research and clinical fields because of its important functions in the central nervous system. An adequate amount of BDNF is critical to develop and maintain normal neuronal circuits in the brain. Given that loss of BDNF function has been reported in the brains of patients with neurodegenerative or psychiatric diseases, understanding basic properties of BDNF and associated intracellular processes is imperative. In this review, we revisit the gene structure, transcription, translation, transport and secretion mechanisms of BDNF. We also introduce implications of BDNF in several brain-related diseases including Alzheimer's disease, Huntington's disease, depression and schizophrenia.

show abstract

“…Of interest a study carried out in a restricted group of patients with HD who were heterozygous for the BDNF Met66 polymorphism showed a later onset of HD [ 111 , 112 , 113 ]. However, subsequent studies failed to confirm this linkage [ 114 , 115 ].…”

Section: Bdnf In Health and Diseasementioning

confidence: 99%

Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production

Brattico

Bonetti

Ferretti

et al. 2021

Cells

View full text Add to dashboard Cite

Motor exercise, such as sport or musical activities, helps with a plethora of diseases by modulating brain functions in neocortical and subcortical regions, resulting in behavioural changes related to mood regulation, well-being, memory, and even cognitive preservation in aging and neurodegenerative diseases. Although evidence is accumulating on the systemic neural mechanisms mediating these brain effects, the specific mechanisms by which exercise acts upon the cellular level are still under investigation. This is particularly the case for music training, a much less studied instance of motor exercise than sport. With regards to sport, consistent neurobiological research has focused on the brain-derived neurotrophic factor (BDNF), an essential player in the central nervous system. BDNF stimulates the growth and differentiation of neurons and synapses. It thrives in the hippocampus, the cortex, and the basal forebrain, which are the areas vital for memory, learning, and higher cognitive functions. Animal models and neurocognitive experiments on human athletes converge in demonstrating that physical exercise reliably boosts BDNF levels. In this review, we highlight comparable early findings obtained with animal models and elderly humans exposed to musical stimulation, showing how perceptual exposure to music might affect BDNF release, similar to what has been observed for sport. We subsequently propose a novel hypothesis that relates the neuroplastic changes in the human brains after musical training to genetically- and exercise-driven BDNF levels.

show abstract

No association between polymorphisms in the BDNF gene and age at onset in Huntington disease

Cited by 15 publications

References 10 publications

Influence of BDNF polymorphisms on Wilson’s disease susceptibility and clinical course

Influence of BDNF polymorphisms on Wilson’s disease susceptibility and clinical course

New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases

Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production

Contact Info

Product

Resources

About