No association between the −399 C&gt;T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

Lindberg, Camilla; Koefoed, Pernille; Es, Hansen; Bolwig, Tom G.; Rehfeld, Jens F.; Mellerup, Erling T.; Jørgensen, Ole Steen; Kessing, Lars Vedel; Werge, Thomas; Haugbøl, Steven; Wang, August G.

doi:10.1111/j.1600-0447.2005.00648.x

Cited by 26 publications

(16 citation statements)

References 21 publications

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“…This is supported by a recent study of a single NPY variant (rs16147) in a Danish sample reporting no association with panic disorder [Lindberg et al, 2006].…”

supporting

confidence: 53%

“…To date, only one study has investigated the influence of a single variant in the NPY gene (7p15.1) in panic disorder failing to detect association of the À399 C/T (rs16147) polymorphism with the disease in a sample of 142 Danish patients [Lindberg et al, 2006].…”

mentioning

confidence: 99%

“…Further SNPs were included in the present study based on previous association findings in nonmental diseases as well as known functional relevance: NPY: SNP1 (rs16157), SNP2 (rs16147, -485T/C [Itokawa et al, 2003] analogous to -399C/T [Mottagui-Tabar et al, 2005;Lindberg et al, 2006]), SNP3 (rs16139, 1128T/C, Leu-7-Pro [Karvonen et al, 1998]), SNP4 (rs9785023, 1258G/A [Skibola et al, 2005]), SNP5 (rs16474); NPY Y1: SNP1 (rs12507653), SNP2 (rs12510104), SNP3 (rs7687423, PstI C/T [Herzog et al, 1997]), SNP4 (rs4691075); NPY Y2: SNP1 (rs11099992), SNP2 (rs12507396), SNP3 (rs1047214), SNP4 (rs11728843); NPY Y5: SNP1 (rs4234955), SNP2 (rs11724320), SNP3 (rs11946004, Gly-426-Gly [Rosenkranz et al, 1998;Blumenthal et al, 2002]). In the present study, SNPs were named using ''rs'' numbers and the respective alleles were called according to NCBI single nucleotide polymorphism database (http://www.ncbi.nlm.nih.gov/projects/SNP/).…”

mentioning

confidence: 99%

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Chromosome 4q31‐34 panic disorder risk locus: Association of neuropeptide Y Y5 receptor variants

Domschke

Hohoff

Jacob

et al. 2008

American J of Med Genetics Pt B

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There is strong evidence for a genetic contribution to the pathogenesis of panic disorder, with a recent linkage study pointing toward a risk locus on chromosome 4q31-q34 [Kaabi et al., 2006]. Since the neuropeptide Y (NPY) system has been reported to be involved in the pathophysiology of anxiety and in particular panic disorder and the genes coding for NPY Y1, Y2, and Y5 receptors are located in the suggested risk region (4q31-q32), variants in the NPY, NPY Y1, Y2, and Y5 genes were investigated for association with panic disorder in a sample of 230 German patients with panic disorder and matched healthy controls. A synonymous (Gly-426-Gly) NPY Y5 coding variant (rs11946004) as well as haplotypes including rs11946004 and an intronic NPY Y5 variant (rs11724320) were significantly associated with panic disorder (P = 0.027), with the effect originating from the subgroup of female patients (P = 0.030), particularly with concurrent agoraphobia (P = 0.002-0.019). No association was observed for any variants located in the genes coding for NPY, NPY Y1, or Y2. The present results provide preliminary support for an influence of NPY Y5 receptor variants on the etiology of panic disorder in a potentially gender-specific manner further strengthening the evidence for a risk locus on chromosome 4q31-q34 in anxiety disorders. However, in order to allow for conclusive evaluation of the present finding and to exclude a false positive result, further studies in larger, independent, preferably family based samples are warranted.

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“…This is supported by a recent study of a single NPY variant (rs16147) in a Danish sample reporting no association with panic disorder [Lindberg et al, 2006].…”

supporting

confidence: 53%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Chromosome 4q31‐34 panic disorder risk locus: Association of neuropeptide Y Y5 receptor variants

Domschke

Hohoff

Jacob

et al. 2008

American J of Med Genetics Pt B

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“…However, this mutation may not confer susceptibility to depression across cultures since it is not found in the Japanese, Chinese Han, Korean and Mexican populations [163][164][165][166]. Association of the T-399C mutation in the NPY promoter with depression [148] was not replication in a later study [148,167].…”

Section: Clinical Studiesmentioning

confidence: 81%

Relevance of Neuropeptide Y (NPY) in Psychiatry

Eaton¹,

Sallee²,

Sah³

2007

CTMC

122

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Extensive preclinical studies suggest neuropeptide Y (NPY) to be involved in stress regulation and coping. NPY counteracts the behavioral consequences of stress and anxiety to maintain emotional homeostasis. NPY is also involved in learning, memory, and cognition, all of which are dysregulated in many psychiatric states. Dense localization of NPY and NPY receptors is found in brain areas implicated in psychopathology such as the amygdala, hippocampus, neocortex, septum, caudate-putamen, hypothalamus and locus coeruleus. Impaired central NPY signaling may therefore be involved in the pathophysiology of depression, anxiety, schizophrenia, alcoholism, and trauma-induced disorders like PTSD. Studies on the readily accessible plasma from psychiatric patients have provided some information on the relevance of NPY as a marker for sympathetic tone in certain conditions. Reports on cerebrospinal fluid (CSF) NPY in subjects with depression indicate a dysregulation of central NPY in this disorder, however, other conditions still need to be investigated.

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“…The human NPY gene contains four exons and is located on chromosome 7p15.1, with the rs16147 (C-399T) polymorphism being located within the upstream promoter region [18,19,20]. This polymorphism affects NPY expression and appears to be responsible for more than half of the variation in expression in vivo [21,22,23].…”

Section: Introductionmentioning

confidence: 99%

Lack of an Association between a Functional Polymorphism in the Neuropeptide Y Gene Promoter and the Presence of Coronary Artery Disease in an Iranian Population

Parizadeh

Jamialahmadi²,

Rooki³

et al. 2014

Ann Nutr Metab

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Background/Aims: Several genetic factors have been identified that may contribute to the risk of coronary artery disease (CAD). Variants of the neuropeptide Y (NPY) gene, whose products play an important role in regulating several physiological functions, have been associated with the risk of CAD in some populations. The purpose of this study was to investigate the relationship between the NPY gene rs16147 polymorphism and the presence of CAD in an Iranian population. Methods: DNA samples of 922 subjects, including 433 with angiographically defined CAD (CAD+), 196 without angiographically defined significant CAD (CAD-) and 293 controls, were genotyped using polymerase chain reaction based on the amplification-refractory mutation system. Logistic regression analyses were performed to assess the association of rs16147 genotypes with the presence of significant CAD. Results: Although logistic regression analysis indicated that the NPY polymorphism rs16147 was nominally associated with an increased risk of CAD (p < 0.05), after adjustment for confounding factors, there was no evidence for any signiﬁcantly increased or decreased risk of CAD with this polymorphism. However, in stratiﬁed analyses, the C allele was signiﬁcantly associated with a reduced risk of CAD in males and subjects who were <50 years of age. Conclusions: This study suggests that the rs16147 polymorphism in the NPY gene may not be a potential contributor to the risk of CAD in an Iranian population.

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No association between the −399 C>T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

Abstract: The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

Cited by 26 publications

References 21 publications

Chromosome 4q31‐34 panic disorder risk locus: Association of neuropeptide Y Y5 receptor variants

Chromosome 4q31‐34 panic disorder risk locus: Association of neuropeptide Y Y5 receptor variants

Relevance of Neuropeptide Y (NPY) in Psychiatry

Lack of an Association between a Functional Polymorphism in the Neuropeptide Y Gene Promoter and the Presence of Coronary Artery Disease in an Iranian Population

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