1997
DOI: 10.1016/s0304-3940(97)00634-4
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No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample

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Cited by 45 publications
(22 citation statements)
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“…45 The C/T766 LRP polymorphism is a silent nucleotide substitution, without RNA processing or amino acid sequence changes. Akin to several other investigators, 35,38,54 we were unable to detect a relationship between AD and the polymorphism C/T 766 of the LRP gene in our sample.…”
Section: Discussioncontrasting
confidence: 84%
“…45 The C/T766 LRP polymorphism is a silent nucleotide substitution, without RNA processing or amino acid sequence changes. Akin to several other investigators, 35,38,54 we were unable to detect a relationship between AD and the polymorphism C/T 766 of the LRP gene in our sample.…”
Section: Discussioncontrasting
confidence: 84%
“…Whereas the reported discrepancies might have been caused by different experimental conditions, our study provides different lines of evidence that ApoE4-bound LRP can cause neuronal cell apoptosis, although the possibility still exists that a hitherto unidentified LRPlike receptor, whose function is inhibitable by RAP and antisense LRP oligonucleotides, is responsible. Multiple groups (Lendon et al, 1997;Wavrant-DeVrieze et al, 1997Kang et al, 1997;Kamboh et al, 1998;Hollenbach et al, 1998;Lambert et al, 1998;Beffert et al, 1999) observed the genetic association of LRP polymorphisms with AD, although this association is controversial (Clatworthy et al, 1997;Fallin et al, 1997;Baum et al, 1998;Scott et al, 1998). The involvement of LRP in ApoE4 neurotoxicity is consistent with the notion that LRP could be a risk factor for AD.…”
Section: Discussionsupporting
confidence: 58%
“…However, an alternative explanation could be that this polymorphism is in linkage disequilibrium with a mutation elsewhere in LRP or a nearby gene. Linkage disequilibrium to another locus has been proposed for the con¯icting results and association of another polymorphism located in the 5 H region of LRP [Clatworthy et al, 1997;Fallin et al, 1997a;Lendon et al, 1997;Wavrant-DeVrieze et al, 1997, 1999. A third missense mutation in exon 6 has recently been identi®ed [Van Leuven et al, 1998] and an association to AD has been reported [Wavrant-DeVrieze et al, 1999].…”
Section: Discussionmentioning
confidence: 99%