“…Whereas the reported discrepancies might have been caused by different experimental conditions, our study provides different lines of evidence that ApoE4-bound LRP can cause neuronal cell apoptosis, although the possibility still exists that a hitherto unidentified LRPlike receptor, whose function is inhibitable by RAP and antisense LRP oligonucleotides, is responsible. Multiple groups (Lendon et al, 1997;Wavrant-DeVrieze et al, 1997Kang et al, 1997;Kamboh et al, 1998;Hollenbach et al, 1998;Lambert et al, 1998;Beffert et al, 1999) observed the genetic association of LRP polymorphisms with AD, although this association is controversial (Clatworthy et al, 1997;Fallin et al, 1997;Baum et al, 1998;Scott et al, 1998). The involvement of LRP in ApoE4 neurotoxicity is consistent with the notion that LRP could be a risk factor for AD.…”