No association between TNFSF15 and IL23R with ulcerative colitis in Koreans

Abstract

Recent genome-wide association studies have shown that some Crohn's disease (CD)-associated loci also contribute to ulcerative colitis (UC) susceptibility. To understand the genetic relationship between the two forms of inflammatory bowel disease, we investigated the well-established CD-susceptibility genes TNFSF15 (tumor necrosis factor ligand superfamily, member 15) and IL23R in Korean patients with UC. Eight TNFSF15 and five IL23R single-nucleotide polymorphisms were genotyped in 654 patients with UC and in 601 healthy controls. There was no association between TNFSF15 or IL23R variants and UC in Korean individuals, in contrast to previous reports of a shared association of the IL23R gene with both CD and UC in Caucasian individuals. Our data suggest that neither TNFSF15 nor IL23R variants contribute to UC susceptibility in Koreans.

Comparative Genetic Analysis of Type 1 Diabetes and Inflammatory Bowel Disease

“…However, the reports of TNFSF15 association with UC in Caucasians have been inconsistent Wang et al, 2010;Haritunians et al, 2010). In contrast to his own previous finding, Yang et al, 2011 reported no association between TNFSF15 and IL23R with UC in Koreans. However, TNFSF15 showed a marginal association with UC in male patients only.…”

Genome-Wide Association Study of Ulcerative Colitis in Koreans Suggests Extensive Overlapping of Genetic Susceptibility With Caucasians

“…A part of this cohort has been studied previously, and determination of phenotypic subgroups of UC was described before. 33,34 Of 1198 patients with UC, 998 were diagnosed at the IBD Clinic of Asan Medical Center, 151 from the Kyung Hee University Hospital, and 49 from the Ewha Womans University Mokdong Hospital, Seoul, Korea, on the basis of conventional clinical, radiologic, endoscopic, and histopathologic criteria. Control subjects for the first stage were from the population control data.…”

“…[23][24][25][26][27][28][29] The TNFSF15 variants contributed to the susceptibility for UC and CD in European populations 8,30 but only for CD in Asians. [31][32][33] So far, only a few studies of UC susceptibility loci have been reported in Asian cohorts. 17,34 One GWAS of UC has been reported in a Japanese population, 17 identifying 5 UC susceptibility genes, which overlapped with the 47 published risk loci in Caucasians.…”

Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations

“…Most of the remaining CD susceptibility loci have not been subjected to validation study in Asian populations. TNFSF15 also showed association with ulcerative colitis (UC), another form of IBD, in Caucasians,8 25 but not in Asians 26 28. As previous Asian studies, including one GWAS, tested rather a limited number of candidate single nucleotide polymorphisms (SNPs) in small sample sizes, additional GWAS in Asians would be helpful to find remaining risk loci and narrow down causative loci by trans-ethnic mapping.…”