No association between vitamin D and atopy, asthma, lung function or atopic dermatitis: a prospective study in adults

Abstract

Studies suggest that vitamin D may be involved in the pathogenesis of allergic disorders, asthma and decreased lung function. However, results are inconsistent and only few prospective studies have examined adults. The purpose of this study was to investigate the association of serum 25-hydroxy vitamin D (s25(OH)D) with atopy, atopic dermatitis (AD), asthma, wheezing and impaired lung function in a prospective study of Danish adults. A random sample of 3471 persons was examined in 2006-2008. Of these, 2308 were re-examined 5 years later. s25(OH)D and specific IgE against four common inhalant allergens were measured by standard procedures. Wheezing, asthma and AD were assessed from questionnaires and lung function was measured by spirometry. We found no statistically significant associations between s25(OH)D and prevalence or incidence of atopy, AD, asthma or wheezing. Associations with lung function were inconsistent. We conclude that vitamin D status does not influence these conditions in adults.

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“…While there are other studies that have not found any association between vitamin D and atopy or asthma [15]. Taking together the available literature, it is not yet possible to confirm or refute the direct role of vitamin D in the development/worsening of allergic diseases, or to assign a role to Vitamin D use in an immunological therapy setting [22].…”

“…The global agenda for anaphylaxis research according to the World Allergy Organization anaphylaxis guidelines also stresses the importance of research in anaphylaxis [14]. Similar work looking at the role of vitamin D in anaphylaxis, asthma and allergies has already been published from other parts of the world [15,16].…”

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

“…The consistency of such a finding in a large number of studies [5][6][7][17][18][19][20][21][22], confirms that the low level of calcidiol in such a disease is not a coincidence, and that calcidiol deficiency has a possible role in the pathogenesis of AD. The controversy in the serum level of calcidiol in AD patients is mainly viewed among adult AD patients, where several studies showed the non-significant alteration of calcidiol levels among patient and control groups [8,9]. This raises the attention that pediatric AD patients are more prone to be worsened with depressed calcidiol level being the age group that may have an increased risk of allergen penetration through the skin, specially that most allergies are initiated in childhood [2].…”

“…Concerning its relation with AD, animal studies, case reports, and randomized clinical trials have suggested the role of calcidiol, through various mechanisms including immunomodulation [4]. Furthermore, an inverse relationship between the severity of AD and calcidiol levels has been previously suggested, and studies have shown that, in individuals with AD who are deficient in calcidiol, repletion of calcidiol results in improvement and decreased severity of the disease [5][6][7]; a notion that has been denied by others [8,9].…”

“…Despite the existence of numerous studies [5][6][7][8][9][10][11][12] tackling the connection that might exist between calcidiol and AD, the value of calcidiol in its treatment is far from clear. Adding to this, the proven existence of calcidiol receptor (VDR) polymorphism in the Egyptian population [13,14] gives more importance to studying the role of calcidiol and to assess its possible role in the treatment of AD in Egyptians; whether it is induced by phototherapy or given as an oral supplementation.…”