No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression

Winter, François‐Laurent De; Emsell, Louise; Bouckaert, Filip; Claes, Lene; Jain, Saurabh; Farrar, Gill; Billiet, Thibo; Evers, Stephan; Stock, Jan Van den; Sienaert, Pascal; Obbels, Jasmien; Sunaert, Stefan; Adamczuk, Katarzyna; Vandenberghe, Rik; Laere, Koen Van; Vandenbulcke, Mathieu

doi:10.1176/appi.ajp.2016.16030319

Cited by 68 publications

(58 citation statements)

References 39 publications

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Section: Introductionmentioning

confidence: 99%

“…However, studies have thus far been limited to amyloid PET [6, 7, 18]. Amyloid was not cross-sectionally associated with subclinical depressive symptoms in a cohort of cognitively normal elderly [6], and was not elevated in older adults with major depressive disorder relative to healthy controls [18]. In contrast, studies by Lavretsky, Kumar and colleagues have shown associations between depressive symptoms in CN, MCI, and late life depression subjects and retention of a PET ligand thought to bind both amyloid and tau [19, 20].…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that tau accumulation in the entorhinal cortex (EC) and inferior temporal lobe (IT), two early sites of accumulation, would be associated with increased depressive symptoms. Further, based on previous findings in CN older adults [6, 18], we hypothesized that depressive symptoms would be more robustly associated with tau relative to amyloid.…”

Section: Introductionmentioning

confidence: 99%

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Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study

Gatchel

Donovan

Locascio

et al. 2017

JAD

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Background Depressive symptoms are common in older adults and associated with increased morbidity and cognitive decline. These symptoms occur during preclinical and prodromal stages of Alzheimer’s disease (AD), but their relationship to tau, one of the main AD proteinopathies, is poorly understood. Objective The objective of this study was to investigate the cross-sectional association between depressive symptoms and cerebral tau (18F T807 (a.k.a. 18F-AV-1451) tau positron emission tomography (PET) imaging) in cognitively normal (CN) older adults. Methods We measured depressive symptoms using the Geriatric Depression Scale (GDS), and in vivo cerebral tau using T807 PET in 111 CN older adults. We employed general linear regression models to evaluate the relationship of GDS score regressed on entorhinal cortex (EC) or inferior temporal (IT) tau in separate backward elimination models. Other predictors included age, sex, and in secondary analyses, amyloid (Pittsburgh Compound B (PiB) PET). Results Higher GDS was significantly associated with greater IT tau (partial r=0.188, p=0.050) and marginally associated with greater EC tau (partial r=0.183, p=0.055). In additional analyses including both linear and quadratic age terms, we found a significant u-shaped relation of GDS to age (p=0.001). Conclusions Results suggest that IT and EC tau are modestly associated with depressive symptoms in CN older adults. Findings suggest a link between depressive symptoms and tau mediated neurodegeneration in a region vulnerable in AD. Future longitudinal studies examining the association of more severe depressive symptoms and cerebral tau accumulation are needed to substantiate this finding and to guide prevention and treatment in AD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study

Gatchel

Donovan

Locascio

et al. 2017

JAD

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“…This is highlighted by the study’s secondary analyses, where there was no difference in amyloid binding observed between early-onset and late-onset depressed subjects (1). Supporting these findings, some previous studies in both cognitively impaired and cognitively intact older adults have similarly failed to associate amyloid burden with depressive symptoms (7; 8).…”

mentioning

confidence: 96%

“…De Winter and colleagues (1) prospectively examined 48 depressed older adults and 52 age- and sex-matched comparison subjects. Participants in this cross-sectional study completed [ 18 F] flutemetamol amyloid positron emission tomography, structural MRI for measurement of hippocampal volume, apolipoprotein E genotyping, and neuropsychological assessments.…”

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confidence: 99%

Lack of a Role for Alzheimer’s Disease Pathology in Late-Life Depression, or Just No Relationship With Amyloid?

Taylor

2017

AJP

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Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease

Langella,

Lopera,

Baena

et al. 2023

Alzheimer's & Dementia

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INTRODUCTIONDepressive symptoms are among early behavioral changes in Alzheimer's disease (AD); however, the relationship between neurodegeneration and depressive symptoms remains inconclusive. To better understand this relationship in preclinical AD, we examined hippocampal volume and depressive symptoms in cognitively unimpaired carriers of the presenilin‐1 (PSEN1) E280A mutation for autosomal dominant AD.METHODSA total of 27 PSEN1 mutation carriers and 26 non‐carrier family members were included. Linear regression was used to test the relationship between hippocampal volume and 15‐item Geriatric Depression Scale.RESULTSCarriers and non‐carriers did not differ in depressive symptoms or hippocampal volume. Within carriers, lower hippocampal volume was associated with greater depressive symptoms, which remained significant after adjusting for age and cognition. This relationship was not significant in non‐carriers.DISCUSSIONHippocampal neurodegeneration may underlie depressive symptoms in preclinical autosomal dominant AD. These findings provide support for the utility of targeting depressive symptoms in AD prevention.Highlights We compared unimpaired autosomal dominant Alzheimer's disease (AD) mutation carriers and non‐carriers. Carriers and non‐carriers did not differ in severity of depressive symptoms. In carriers, hippocampal volume was inversely associated with depressive symptoms. Depressive symptoms may be a useful target in AD prevention.

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No Association of Lower Hippocampal Volume With Alzheimer’s Disease Pathology in Late-Life Depression

Abstract: Lower hippocampal volume was not related to amyloid pathology in this sample of patients with late-life depression. These data counter the common belief that changes in hippocampal volume in late-life depression are due to prodromal Alzheimer's disease.

Cited by 68 publications

References 39 publications

Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study

Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study

Lack of a Role for Alzheimer’s Disease Pathology in Late-Life Depression, or Just No Relationship With Amyloid?

Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease

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