No association of the TGF-b1 gene polymorphisms with the renal progression in autosomal dominant polycystic kidney disease (ADPKD) patients

Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China

“…Both subjects (diseased or normal) showed the G-allele at codon 25 encoding Arg. This finding along with the recent demonstration about the variability at this site is also absent in populations from Korea and Japan (35,36) suggests that this polymorphism is generally not found in populations of Asian ancestry. Further, we also observed no genetic alteration at position 263 in all subjects.…”

Association of transforming growth factor-β1 polymorphisms with the risk of chronic kidney diseases

“…Of these, 169 papers were excluded according to the inclusion and exclusion criteria. Nine studies 1,[10][11][12][13][14][15][16][17] were enrolled in our analysis for the association between TGF-b1 gene +869 T/C, À800 G/A, À509 T/C and +915 G/C polymorphisms and CKD risk (Figure 1). Among the enrolled nine studies, six for +869 T/C, one for À800 G/A, three for À509 T/C and five for +915 G/C (Figure 1).…”

“…Six studies [12][13][14][15][16][17] were identified for the analysis of the association between TGF-b1 gene +869 T/C polymorphism and CKD risk (Table 1). Three studies 12,13,15 were performed in Caucasians, while three 14,16,17 in Asians.…”

“…Three studies 12,13,15 were performed in Caucasians, while three 14,16,17 in Asians. A total of 1418 cases and 1024 controls were included.…”

“…1,[10][11][12][13][14][15][16][17] However, the results were not consistent among the reported studies. Meta-analysis is a good way to summarize the available data to provide robust results.…”