No benefit of intraoperative whole blood sequestration and autotransfusion during coronary artery bypass grafting: results of a randomized clinical trial

Ramnath, A.N; Naber, Harry R.; Boer, A de; Leusink, J.A.

doi:10.1016/s0022-5223(03)00105-3

Cited by 18 publications

(6 citation statements)

References 24 publications

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“…(RR, 0.42, 95% CI, 0.24–0.74), but not for orthopedic (RR, 0.77; 95% CI, 0.51–1.04) or cardiac surgery (RR, 0.79; 95% CI, 0.60–1.06) 119,138 . Furthermore, in a later randomized controlled trial on 144 patients undergoing cardiac surgery, ANH did not result in a reduction of the ABT rate 139 …”

Section: Module IV Nonpharmacological Alternatives: Autologous Bloodmentioning

confidence: 89%

Spanish consensus statement on alternatives to allogeneic transfusions: the ‘Seville document’

Leal-Noval

Múñoz

Páramo

et al. 2006

Transfus Alt Transfus Med

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SUMMARY The Consensus Document on Alternatives to Allogeneic Blood Transfusion (AABT) has been drawn up by a panel of experts from five scientific societies. The Spanish societies of anesthesiology (SEDAR), critical care medicine and coronary units (SEMICYUC), hematology and hemotherapy (AEHH), blood transfusion (SETS), and thrombosis and hemostasis (SETH) have sponsored and participated in this consensus document. Alternatives to blood transfusion have been divided into pharmacological and nonpharmacological, with four modules and 12 topics. The main objective variable was the reduction of allogeneic blood transfusions and/or the number of transfused patients. The extent to which this objective was achieved by each AABT was evaluated using the Delphi methodology, which classifies the grades of recommendation from ‘A’ (supported by controlled studies) to ‘E’ (noncontrolled studies and expert opinion). The experts concluded that most of the indications for AABT only attained middle or low grades of recommendation, ‘C’, ‘D’ or ‘E’, thus indicating the need for further controlled studies.

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Section: Module IV Nonpharmacological Alternatives: Autologous Bloodmentioning

confidence: 89%

Spanish consensus statement on alternatives to allogeneic transfusions: the ‘Seville document’

Leal-Noval

Múñoz

Páramo

et al. 2006

Transfus Alt Transfus Med

View full text Add to dashboard Cite

show abstract

“…[165][166][167][168][169][170][171][172][173][174][175][176][177][178] Additional metaanalyses of RCTs indicate that ANH combined with intraoperative red blood cell recovery compared with intraoperative red blood cell recovery alone is effective in reducing the volume of allogeneic blood transfused (Category A1-B evidence) and is equivocal regarding the number of patients transfused with allogeneic blood (Category A1-E evidence). [165][166][167][168][169][170][171][172][173][174][175][176][177][178] Additional metaanalyses of RCTs indicate that ANH combined with intraoperative red blood cell recovery compared with intraoperative red blood cell recovery alone is effective in reducing the volume of allogeneic blood transfused (Category A1-B evidence) and is equivocal regarding the number of patients transfused with allogeneic blood (Category A1-E evidence).…”

Section: Practice Parametersmentioning

confidence: 99%

Practice Guidelines for Perioperative Blood Management

2015

Anesthesiology

602

104

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“…Physicians make transfusion decisions based upon their past teaching and enculturation. As a result of the lack of evidence based medicine supporting the transfusion decision, transfusion during CABG surgery varies widely [3,4]. In other way, transfused patients in general are immunosuppressive [5,6] and unfortunately, these patients have been associated with postoperative infection in a dose-dependent model by blood units transfused [7].…”

Section: Introductionmentioning

confidence: 99%

“…The combined effect of postoperative transfusion on patients undergoing isolated CABG in terms of cumulative morbidity and perioperative mortality and their resource utilization [total intensive care unit (ICU) hours, duration of intubations, hospital length of stay (HLOS), post operation length of stay (PLOS)] is less known. The purposes of this study were [1] to identify preoperative risk factors that may be associated with blood transfusion, [2] to evaluate the effect of blood transfusion on 30 days mortality and morbidity in patients undergoing isolated CABG, and [3] to evaluate the effect of blood transfusion on resource utilization. …”

Section: Introductionmentioning

confidence: 99%

Transfusion associated in-hospital mortality and morbidity in isolated Coronary Artery Bypass Graft surgery

et al. 2009

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AbstractTransfusion after cardiac surgery is very common. This rate varies between institutions and has remained high despite established transfusion guidelines. We analyzed our database of patients who underwent isolated CABG (Coronary Artery Bypass Graft) to determine the predictive factors of homologous transfusion and associated postoperative morbidity, mortality and resource utilization. All 14,152 patients who underwent first-time isolated CABG, with or without cardiopulmonary bypass (CPB) who had postoperative homologous transfusion between February 2002 and March 2008 in Tehran Heart Center, were evaluated retrospectively. Overall, 16.5% of patients received transfusion. Transfused patients demonstrated a significantly higher incidence of postoperative complications (cardiac, infectious, ischemic, reoperation) and mortality (p<0.001). Homologous blood transfusion effect on mortality, morbidity and resource utilization. By Multivariable logistic regression analysis adjusted for confounders: Homologous blood transfusion effect on Mortality (30-days) (OR=3.976, p<0.0001), Prolonged ventilation hours (OR=4.755, p<0.0001), Total ICU hours (β =14.599, p<0.0001), Hospital length of stay (β =1.141, p<0.0001), Post surgery length of stay (β =0.955, p<0.0001). We conclude that the isolated CABG patients receiving blood transfusion have significantly higher mortality, morbidity and resource utilization. Homologous blood transfusion is an independent factor of increased resource utilization, morbidity and mortality.

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No benefit of intraoperative whole blood sequestration and autotransfusion during coronary artery bypass grafting: results of a randomized clinical trial

Abstract: In coronary artery bypass grafting there is no effect of heparin or citrate intraoperative whole blood sequestration with regard to blood loss or use of allogeneic blood.

Cited by 18 publications

References 24 publications

Spanish consensus statement on alternatives to allogeneic transfusions: the ‘Seville document’

Spanish consensus statement on alternatives to allogeneic transfusions: the ‘Seville document’

Practice Guidelines for Perioperative Blood Management

Transfusion associated in-hospital mortality and morbidity in isolated Coronary Artery Bypass Graft surgery

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