No change in lymph node positivity rate despite increased lymph node yield and improved survival in colon cancer

Method of pedicle division during laparoscopic right hemicolectomy affects lymph node yield and short‐term outcomes

“…It is possible that RHC‐IC is more likely to achieve a more extensive dissection, particularly if the superior mesenteric vessels are dissected, and thereby increasing the chance of detecting positive nodes. However, there was no difference in node‐positive rate between the two groups, so stage migration was not evident, which is consistent with previously published work looking at the effects of increasing lymph yield over a 15‐year period on cancer stage …”

“…However, there was no difference in node-positive rate between the two groups, so stage migration was not evident, which is consistent with previously published work looking at the effects of increasing lymph yield over a 15-year period on cancer stage. 14 We also assessed whether BMI affected lymph node yield. For RHC-IC there was no correlation between BMI and lymph node yield.…”

Lymph Node Evaluation for Colon Cancer in Routine Clinical Practice: A Population-Based Study

“…In their analysis of data from the Surveillance, Epidemiology, and End Results Program in the United States, Parsons et al 2 reported that the proportion of surgeries in which 12 or more lns were evaluated increased from 35% in 1988-1990 to 74% in 2006 -2008. Similarly, a population-based study from the Netherlands found that the rate of adequate ln yield increased to 59% in 2009-2011 from 13% in 2000-2002 7 . Population-based data from Ontario have show n similar temporal trends: during 1991-1993, 10 or more lns were resected in only 26% of patients; by 2004, the proportion of resections with more than 12 lns evaluated had increased to approximately 70% 8,9 .…”

Interlaboratory Variability in the Histologic Grading of Colorectal Adenocarcinomas in a Nationwide Cohort

“…29 Large nationwide cohort studies from the Netherlands reported PD adenocarcinoma in 13.4% and 16% to 19% of rectal and colon carcinomas, respectively. [30][31][32][33] The interlaboratory differences in differentiation grading in the present study could be only partly explained by differences in case mix between laboratories, as after adjustment for these differences 4 (11%) laboratories still reported a significantly lower (n = 2) or higher (n = 2) proportion of PD adenocarcinomas. Selection of the median laboratory as reference laboratory is arbitrary, because the proportion of this laboratory might not necessarily indicate greater accuracy of diagnosis.…”