No conflict of interest?

Dean, Benjamin; Davies, Benjamin M

doi:10.1007/s00586-013-2899-x

Cited by 8 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study has suggested antibiotic treatment as an effective option for a specific subgroup of patients with Modic type 1 changes [9]. Significant controversy has followed, with a number of authors raising concerns about the methodology and conclusion of that study [41][42][43][44][45][46][47][48][49][50][51][52]. Within the restrictions of our specimen size, and our study being a bone micro-architecture and remodelling study, not aimed at investigating bacterial infection, our histological slides of the bone biopsies (H&E stained) did not show associated oedema and no cellular infiltrate to indicate overt inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…However, the material analysed in the present study included bone biopsies only, and not intervertebral disc which may contain bacteria and show inflammation. This remains a controversial topic, in need of further research as suggested by numerous letters to this journal [41][42][43][44][45][46][47][48][49][50][51][52]. Hence, evidence supporting the biomechanical and biochemical hypotheses is still not sufficient, and it remains unclear how they may play a synergistic role in the development of Modic changes in the human body [3].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling

et al. 2014

View full text Add to dashboard Cite

Purpose In the literature, inter-vertebral MRI signal intensity changes (Modic changes) were associated with corresponding histological observations on endplate biopsies. However, tissue-level studies were limited. No quantitative histomorphometric study on bone biopsies has yet been conducted for Modic changes. The aim of this study was to characterise the bone micro-architectural parameters and bone remodelling indices associated with Modic changes. Methods Forty patients suffering from disabling low back pain, undergoing elective spinal surgery, and exhibiting Modic changes on MRI (Modic 1, n = 9; Modic 2, n = 25; Modic 3, n = 6), had a transpedicular vertebral body biopsy taken of subchondral bone. Biopsies were first examined by micro-CT, for 3D morphometric analysis of bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular separation, trabecular number, and structure model index. Then, samples underwent histological analysis, for determination of bone remodelling indices: osteoid surface to bone surface ratio (OS/BS), eroded surface to bone surface (ES/BS) and osteoid surface to eroded surface ratio (OS/ES). Results Micro-CT analysis revealed significantly higher BV/TV (up to 70 % increase, p \ 0.01) and Tb.Th (up to ?57 %, p \ 0.01) in Modic 3 biopsies, compared to Modic 1 and 2. Histological analysis showed significantly lower OS/BS in Modic 2 biopsies (more than 28 % decrease, p \ 0.05) compared to 1 and 3. ES/BS progressively decreased from Modic 1 to 2 to 3, whereas OS/ES progressively increased with significantly higher values in Modic 3 (up to 159 % increase, p \ 0.05) than in Modic 1 and 2. Conclusions Significant differences were found in bone micro-architectural parameters and remodelling indices among Modic types. Modic 1 biopsies had evidence of highest bone turnover, possibly due to an inflammatory process; Modic 2 biopsies were consistent with a reduced bone formation/remodelling stage; Modic 3 biopsies suggested a more stable sclerotic phase, with significantly increased BV/TV and Tb.Th compared to Modic 1 and 2, linked to increased bone formation and reduced resorption.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling

et al. 2014

View full text Add to dashboard Cite

show abstract

Overview: the role of Propionibacterium acnes in nonpyogenic intervertebral discs

Chen

Cao

Zhou

et al. 2016

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Propionibacterium acnes (P. acnes), an important opportunistic anaerobic Gram-positive bacterium, causes bone and joint infections, discitis and spondylodiscitis. Accumulated evidence suggested that this microbe can colonise inside intervertebral discs without causing symptoms of discitis. Epidemiological investigation shows that the prevalence ranges from 13 % to 44 %. Furthermore, colonisation by P. acnes inside nonpyogenic intervertebral discs is thought to be one pathogen causing sciatica, Modic changes and nonspecific low back pain. Specially, patients can attain significant relief of low back pain, amelioration of Modic changes and alleviation of sciatica after antibiotic therapy, indicating the role of P. acnes in these pathological changes. However, until now, there were hypotheses only to explain problems such as how P. acnes access intervertebral discs and what the exact pathological mechanism it employs during its latent infection period. In addition, research regarding diagnostic procedures and treatment strategies were also rare. Overall, the prevalence and possible pathological role that P. acnes plays inside nonpyogenic intervertebral discs is summarised in this paper.

show abstract

GRP-025 Application of a Pressure Ulcer Prevention and Treatment Protocol in the Fatebenefratelli and Ophthalmic Hospital in Milan

et al. 2013

View full text Add to dashboard Cite

and dexamethasone treatment and picked up their medicines in our hospital. The data were obtained from a Diraya computer system of the Andalusian health system. The following data were obtained: sex, age, whether they had anticoagulant treatment or not and if they had, what type of anticoagulation they received. Results The total number of patients was 31, 16 males and 15 females, with an average age of 61.7 years. Of these 31 patients treated with lenalidomide plus dexamethasone, only 9 patients received antithrombotic prophylactic treatment. Of the 22 who did not receive it, there were two cases of episodes of deep arterial thrombosis. Conclusions Most of the patients with multiple myeloma who come to our pharmacy service are without antithrombotic prophylactic treatment with the risk that this situation entails. As pharmacists we consider it necessary to remind haematologists of the necessity both of prescribing such treatment in order to avoid future complications, and of monitoring that these recommen dations are observed, in order to guarantee the safe use of lenalidomide. No conflict of interest. ApplicAtion of A pressure ulcer prevention And treAtment protocol in the fAtebenefrAtelli And ophthAlmic hospitAl in milAn

show abstract

No conflict of interest?

Cited by 8 publications

References 2 publications

Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling

Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling

Overview: the role of Propionibacterium acnes in nonpyogenic intervertebral discs

GRP-025 Application of a Pressure Ulcer Prevention and Treatment Protocol in the Fatebenefratelli and Ophthalmic Hospital in Milan

Contact Info

Product

Resources

About