No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory

Gilboa, Asaf; Moscovitch, Morris

doi:10.1016/j.neuron.2021.04.025

Cited by 96 publications

(89 citation statements)

References 219 publications

(312 reference statements)

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“…Examining which of these categoric memories are abnormal would shed light on a pathological condition of the autobiographical memory structure. As mentioned earlier, both specific and general categoric memory are related to hippocampal function (Gilboa & Moscovitch, 2021), and hippocampal dysfunction may impair general categoric memory. However, there are robust findings that older and depressed individuals have more semantic and categoric memories (Devitt, Addis, & Schacter, 2017;Williams et al, 2007).…”

Section: Discussionmentioning

confidence: 73%

“…Previous studies have confirmed that the hippocampus underlies the encoding and retrieval of specific autobiographical memories (Barry & Maguire, 2019;Gilboa & Moscovitch, 2021;Moscovitch et al, 2016;Squire, Genzel, Wixted, & Morris, 2015) as well as general categoric memories (Addis et al, 2004;Gilboa & Moscovitch, 2021;Holland, Addis, & Kensinger, 2011;Renoult et al, 2012;St-Laurent, Moscovitch, Levine, & McAndrews, 2009;Young et al, 2012). This is probably because components of autobiographical memory retrieval involving the hippocampus, such as the generation of a conceptual frame (Conway, 2009;Irish & Piguet, 2013) and visuospatial imagery (Addis et al, 2004), overlap between specific and general categoric memories.…”

Section: Discussionmentioning

confidence: 80%

“…Pattern separation ability is thought to reflect the function of CA3 and the dentate gyrus, which are subregions of the hippocampal structure (Stark et al, 2019), especially contributing to separate memories that are complex and occur over time (Moscovitch et al, 2016;Yonelinas, 2013); thus, it enables the retention of unique aspects of specific events and leads to greater AMS. As a different mechanism, categoric memory based on abstract representations corresponding to a part of autobiographical facts (Renoult et al, 2012(Renoult et al, , 2016 may be represented by the interaction between the vmPFC and the anterior hippocampus (Gilboa & Marlatte, 2017;Gilboa & Moscovitch, 2021). Thus, researchers should identify the role of subregions and related areas of the hippocampal structure in AMS.…”

Section: Discussionmentioning

confidence: 99%

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Autobiographical memory specificity and mnemonic discrimination

Matsumoto¹,

Kobayashi²,

Takano³

2021

Preprint

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Autobiographical memory specificity (AMS), which is the tendency to recall events that occurred at a particular time and place, enables everyday functioning, such as well-being and social problem-solving skills. A mechanism that may be important for AMS, hinting at the neural basis, is the possibility that pattern separation of similar events contributes to AMS. Pattern separation is an essential component of episodic memory and may allow us to encode and retain the unique aspects of events, making it easier to retrieve event-specific knowledge during retrieval. We examined the hypothesis that poor pattern separation is associated with a low proportion of specific memories and a high proportion of categoric memories derived from a lack of details regarding events. In Experiment 1 (N = 94) and Experiment 2 (preregistered; N = 99), participants completed the Autobiographical Memory Test (AMT), which measures AMS, and a pattern separation measure. We coded AMT responses conventionally and then further classified the categoric memory responses based on abstract representations that contained words denoting high frequency and those derived from lacking context information such as when and/or where event occurs. As predicted, the lure discrimination score was positively correlated with specific memories and negatively correlated with categoric memories derived from lacking context information. These results were invariant when controlling for participants’ characteristics, general intelligence, and recognition measures. We propose to distinguish between these two types of general categoric memory and discuss the development of an integrative model of autobiographical memory structure.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Autobiographical memory specificity and mnemonic discrimination

Matsumoto¹,

Kobayashi²,

Takano³

2021

Preprint

View full text Add to dashboard Cite

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“…As a control task, participants were asked to verbally describe complex photographs. One notable finding from these data was evidence supporting a temporally graded and time-limited role of the hippocampus in the recall of autobiographical memories-an issue that has been discussed at length with several established "camps" in the literature (for recent reviews of various hypotheses, see Squire et al, 2015;Barry and Maguire, 2019;Yonelinas et al, 2019;Gilboa and Moscovitch, 2021). Overt recall was employed to provide experimental knowledge of the type of information being retrieved during recall (Gilmore et al, 2021b) as this, along with the age of a recalled memory, appears to be a critical variable in the debate of hippocampal contributions to remote recall.…”

Section: Body Textmentioning

confidence: 88%

A comparison of single and multi-echo processing of fMRI data during overt autobiographical recall

Gilmore¹,

Agron²,

González-Araya³

et al. 2021

Preprint

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Recent years have seen an increase in the use of multi-echo fMRI designs by cognitive neuroscientists. Acquiring multiple echoes allows one to reduce thermal noise and identify nuisance signal components in BOLD data (Kundu et al., 2012). At the same time, multi-echo acquisitions increase data processing complexity and may incur a cost to the temporal and spatial resolution of the acquired data. Here, we re-examine a multi-echo dataset (Gilmore et al., 2021a) analyzed using multi-echo ICA (ME-ICA) and focused on hippocampal activity during the overly spoken recall of recent and remote autobiographical memories. The goal of the present series of analyses was to determine if ME-ICA’s theoretical denoising benefits might lead to a practical difference in the overall conclusions reached. Compared to single echo data, ME-ICA led to qualitatively different conclusions regarding hippocampal contributions to autobiographical recall: whereas the single echo analysis largely failed to reveal hippocampal activity relative to an active baseline, ME-ICA results supported predictions of the Standard Model of Consolidation and a time limited hippocampal involvement (Alvarez and Squire, 1994). These data provide a practical example of the benefits multi-echo denoising in a naturalistic memory paradigm and demonstrate how they can be used to address long-standing theoretical questions.

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“…While the formation of higher-order associations depends on the strength of their corresponding first-order associations, once robust higher-order associations are formed, higher-order associations are not simply an extension of first-order learning. Neural structures that represent reward value and motivation cannot independently support representations of intrinsic higher order relations (Wimmer and Shohamy, 2012;Gilboa et al, 2014;Gilboa and Moscovitch, 2021). Lesion studies suggest that firstorder and higher-order associations are supported by partially overlapping, but distinct, neuroanatomical structures that seem to differ in their contributions to first-order and higher-order associations.…”

Section: Introductionmentioning

confidence: 98%

Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning

Dhamija

Wong

Gilboa

2022

Front. Behav. Neurosci.

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Stimuli in reality rarely co-occur with primary reward or punishment to allow direct associative learning of value. Instead, value is thought to be inferred through complex higher-order associations. Rodent research has demonstrated that the formation and maintenance of first-order and higher-order associations are supported by distinct neural substrates. In this study, we explored whether this pattern of findings held true for humans. Participants underwent first-order and subsequent higher-order conditioning using an aversive burst of white noise or neutral tone as the unconditioned stimuli. Four distinct tones, initially neutral, served as first-order and higher-order conditioned stimuli. Autonomic and neural responses were indexed by pupillometry and evoked response potentials (ERPs) respectively. Conditioned aversive values of first-order and higher-order stimuli led to increased autonomic responses, as indexed by pupil dilation. Distinct temporo-spatial auditory evoked response potentials were elicited by first-order and high-order conditioned stimuli. Conditioned first-order responses peaked around 260 ms and source estimation suggested a primary medial prefrontal and amygdala source. Conversely, conditioned higher-order responses peaked around 120 ms with an estimated source in the medial temporal lobe. Interestingly, pupillometry responses to first-order conditioned stimuli were diminished after higher order training, possibly signifying concomitant incidental extinction, while responses to higher-order stimuli remained. This suggests that once formed, higher order associations are at least partially independent of first order conditioned representations. This experiment demonstrates that first-order and higher-order conditioned associations have distinct neural signatures, and like rodents, the medial temporal lobe may be specifically involved with higher-order conditioning.

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No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory

Cited by 96 publications

References 219 publications

Autobiographical memory specificity and mnemonic discrimination

Autobiographical memory specificity and mnemonic discrimination

A comparison of single and multi-echo processing of fMRI data during overt autobiographical recall

Early Auditory Event Related Potentials Distinguish Higher-Order From First-Order Aversive Conditioning

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