Disgust and dehumanization both dampen empathy toward outgroups, and dehumanization also often involves representing the target as a disgusting animal. Therefore, we examined the relationship between disgust and dehumanization, documenting robust relationships between them in Americans’ evaluations of a variety of stigmatized groups (Studies 1-2). Since disgust is reliably elicited in the presence of disease threats, we then investigated its relationship with the dehumanization of Chinese people, a group stigmatized due to their association with the COVID-19 pandemic. Americans who felt more vulnerable to disease expressed more disgust toward, and dehumanization of, Chinese people (Study 3). In a final study, we found Americans’ disease concerns predicted their anti-immigrant attitudes, an effect wholly mediated by their disgust toward, and dehumanization of, immigrants. However, this only occurred when the threat of contracting COVID-19 was made salient (Study 4). We conclude that a constellation of disease concerns, disgust, and dehumanization can foment xenophobic attitudes.