No cross‐reactions between tetrazepam and other benzodiazepines: a possible chemical explanation

Occupational allergic contact dermatitis from tetrazepam in nurses

“…In the literature, we found only two case reports regarding a positive patch test to diazepam in patients with cutaneous reaction to tetrazepam (1, 8): the first patient was suffering from an occupational contact dermatitis and also had to crush tablets containing diazepam; the second case reported a maculopapular eruption after ingestion of tetrazepam tablets and denied previous intake of diazepam. In several other reports (2, 4, 11, 12, 14–20), patch tests (and oral provocation tests) with diazepam remained negative, which was also the case in our patients, as diazepam (Valium ® crushed tablet 30% pet. or diazepam pure substance 10% pet.)…”

“…6 and 7 of our series presented with a positive patch test to another benzodiazepine which they handled during work, namely lorazepam (Temesta ® ). In the literature, 12 tetrazepam‐allergic patients tested negative to this compound (2, 15–18).…”

Airborne contact dermatitis to tetrazepam in geriatric nurses – a report of 10 cases

“…[2][3][4][5][6][7][8] Less frequently, Stevens Johnson syndrome, [6][7][8]11 toxic epidermal necrolysis, 12,13 erythema multiforme 7,14 and photodermatitis/phototoxicity 15,16 were linked to tetrazepam intake. In addition, there are individual case reports of acute generalized exanthematous pustulosis (AGEP), 17 fixed drug eruption 8 and drug rash with eosinophilia (DRESS) 18 described. In contrast, airborne contact eczema [19][20][21][22] was observed after occupational exposure to tetrazepam, without previous intake of tetrazepam.…”

“…Common adverse reactions after systemic intake are neurological and gastrointestinal, while cutaneous reactions to tetrazepam are rare and comprise in the majority maculopapular exanthems. [2][3][4][5][6][7][8] Recently Vander Hulst et al reported an occupational airborne dermatitis to tetrazepam in 10 nurses who were referred for evaluation of facial and ⁄ or hand dermatitis. 9…”

Tetrazepam Allergy: A Case Series of Cutaneous Adverse Events

“…S1 1 , diazepam has great structural homology with tetrazepam, deviating only at R4 substitution (aromatic ring (T) and cyclohexene ring (D)). Although the chemical structure of these 2 muscle relaxants is very similar, with the exception of one report, all other reports failed to demonstrate cross-reactivity (3)(4)(5).…”