No Detection of 'High-risk' Human Papillomaviruses in a Group of Iranian Women with Breast Cancer

Ahangar-Oskouee, Mahin; Shahmahmoodi, Shohreh; Jalilvand, Somayeh; Mahmoodi, Mahmood; Ziaee, Abed-Ali; Esmaeili, H; Keshtvarz, Maryam; Sabet, L Pishraft; Yousefi, Maryam; Mollaei-Kandelous, Yaghoob; Mokhtari‐Azad, Talat; Nategh, R

doi:10.7314/apjcp.2014.15.9.4061

Cited by 27 publications

(20 citation statements)

References 32 publications

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“…The values identified in our study were lower than those described in a meta-analysis of 29 published studies, in which the prevalence rates of HPV infection were 23% in BC samples and 12.9% in normal cases. However, in contrast to the present study findings, studies conducted in France, Iran and Switzerland failed to detect the presence of HR-HPVs in benign breast tissue specimens of the related population [25][26][27].…”

Section: Discussioncontrasting

confidence: 99%

Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study

Sher

Salman

Kuliński

et al. 2020

Cancers

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Human papillomavirus (HPV) has been implicated in the etiology of a variety of human cancers. Studies investigating the presence of high-risk (HR) HPV in breast tissue have generated considerable controversy over its role as a potential risk factor for breast cancer (BC). This is the first investigation reporting the prevalence and type distribution of high-risk HPV infection in breast tissue in the population of Qatar. A prospective comparison blind research study herein reconnoitered the presence of twelve HR-HPV types’ DNA using multiplex PCR by screening a total of 150 fresh breast tissue specimens. Data obtained shows that HR-HPV types were found in 10% of subjects with breast cancer; of which the presence of HPV was confirmed in 4/33 (12.12%) of invasive carcinomas. These findings, the first reported from the population of Qatar, suggest that the selective presence of HPV in breast tissue is likely to be a related factor in the progression of certain cases of breast cancer.

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Section: Discussioncontrasting

confidence: 99%

Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study

Sher

Salman

Kuliński

et al. 2020

Cancers

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“…This observation is consistent with the findings of other studies from different geographical areas which reported 32% and 18% of benign tissues were positive in Turkish and Australian populations, respectively2233. However in contrast to our findings, studies conducted in France, Iran, and Switzerland failed to detect the presence of HR-HPVs in benign breast tissue specimens of the related population232434.…”

Section: Discussioncontrasting

confidence: 99%

Association of High Risk Human Papillomavirus and Breast cancer: A UK based Study

Salman

Davies

Majidy

et al. 2017

Sci Rep

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Infection by human papillomaviruses (HPVs) has been implicated in the aetiology of a variety of cancers. Studies evaluating the presence of HPVs in breast cancer (BC) have generated considerable controversy. To date, most studies have focused on the presence of viral DNA in BC; however there are important gaps in evidencing the role of HPV persistence in the invasiveness of BC. While these studies have been conducted in several countries, none, on the presence and biological activity of high risk (HR) HPV in BC has been done in the UK. Hence, we aimed to investigate these gaps by screening a total of 110 fresh breast tissue specimens from UK patients for the presence of twelve HR-HPV types DNA using PCR and Sanger sequencing. Samples positive for HPV-DNA were screened for viral oncoprotein expression using western blot and dot blot. Data obtained showed the presence of HR-HPVs in 42% of breast tissues of which the viral activity was only confirmed in a number of invasive carcinomas (5/26). This finding, the first to report in the UK, suggests that the selective expression of viral oncoprotein in invasive cases may propose a role for HR-HPVs in the development of some types of BC.

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“…50 Additionally, a few studies from Iran showed varying HPV prevalence in breast cancer (14-49%) in Iranian women. 45,[51][52][53] On the other hand, it is important to highlight that a study on cervical samples in Qatari women found HPV prevalence of 55%, which also supports our data. 54 Indeed, one of the key findings in our study is the predominance of HPV genotypes -52 and −56 in breast cancer from Qatari women.…”

Section: Discussionsupporting

confidence: 90%

The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer

Gupta

Jabeen

Al-Sarraf

et al. 2020

Human Vaccines & Immunotherapeutics

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High-risk human papillomaviruses (HPV) can be present and cooperate with Epstein–Barr virus (EBV) to promote the onset and/or progression of various cancers including cervical, breast, head and neck as well as colorectal. In this investigation, we explored the co-prevalence of high-risk HPV and EBV in 74 breast cancer tissues from Qatari women using polymerase chain reaction. We found that high-risk HPV and EBV are present in 48/74 (65%) and 36/74 (49%) of the cases, respectively. While we noted that the presence of HPV presence is associated with triple-negative breast cancer (TNBC) ( p = .008), however, the presence of EBV did not correlate with any breast cancer subgroup. Moreover, our data revealed that high-risk HPV and EBV are co-present in 35/74 (47%) of the samples and their co-presence is significantly associated with tumor grade ( p = .04) and tumor stage ( p = .04). These data indicate that HPV and EBV are commonly co-present in breast cancer and their association could be linked with a more aggressive tumor phenotype. Thus, further investigations are essential to understand the underlying mechanisms of HPV and EBV cooperation in breast carcinogenesis.

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No Detection of 'High-risk' Human Papillomaviruses in a Group of Iranian Women with Breast Cancer

Cited by 27 publications

References 32 publications

Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study

Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study

Association of High Risk Human Papillomavirus and Breast cancer: A UK based Study

The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer

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